| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:BB-Cl-Yne
CAS:2219324-71-5
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:BB-Cl-Yne
CAS:2219324-71-5
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:BB-Cl-Yne
CAS:2219324-71-5
Purity:98% Package:500μg;1mg;5mg
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:BB-Cl-Yne
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| | BB-Cl-Yne Basic information |
| Product Name: | BB-Cl-Yne | | Synonyms: | BB-Cl-Yne;BBClYne,BB Cl Yne;[1,1'-Biphenyl]-4-carboxamide, N-[(1S)-1-(1H-benzimidazol-2-yl)-4-[(2-chloro-1-iminoethyl)amino]butyl]-4'-ethynyl- | | CAS: | 2219324-71-5 | | MF: | C28H26ClN5O | | MW: | 483.99 | | EINECS: | | | Product Categories: | | | Mol File: | 2219324-71-5.mol |  |
| | BB-Cl-Yne Chemical Properties |
| density | 1.24±0.1 g/cm3(Predicted) | | solubility | DMF: 20 mg/ml; DMF:PBS (pH 7.2) (1:5): 0.16 mg/ml; DMSO: 5 mg/ml | | form | A crystalline solid | | pka | 11.43±0.10(Predicted) |
| | BB-Cl-Yne Usage And Synthesis |
| Description | BB-Cl-Yne is a cell-permeable derivative of the protein arginine deiminase (PAD) inhibitor BB-Cl-amidine that contains an alkyne moiety for use in click chemistry reactions. BB-Cl-Yne inhibits PAD1-4 and has been used for labeling PADs in cell-free and cell-based assays, followed by click reactions with azide-modified TAMRA or biotin reporters. | | Uses | BB-Cl-Yne is a protein arginine deiminase (PAD) inhibitor with Ki values of PAD1-4.are 6400, 3600, 10800, 4900 M-1min-1 respectively. BB-Cl-Yne can be used as a click probe to label PAD[1]. | | References | [1] Nemmara VV, et al. The Development of Benzimidazole-Based Clickable Probes for the Efficient Labeling of Cellular Protein Arginine Deiminases (PADs). ACS Chem Biol. 2018 Mar 16;13(3):712-722. DOI:10.1021/acschembio.7b00957 |
| | BB-Cl-Yne Preparation Products And Raw materials |
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