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Product Name:3-Methoxy-5-(Methoxycarbonyl)benzoic acid
CAS:71590-08-4
Purity:96%Min Package:10g 100g 500g
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METHYL 5-METHOXY-ISOPHTHALATE manufacturers
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| | METHYL 5-METHOXY-ISOPHTHALATE Basic information |
| Product Name: | METHYL 5-METHOXY-ISOPHTHALATE | | Synonyms: | METHYL 5-METHOXY-ISOPHTHALATE;3-METHOXYCARBONYL-5-METHOXYBENZOIC ACID;3-METHOXYCARBONYL-5-METHOXYBENZOIC ACIDMETHYL 5-METHOXY-ISOPHTHALATE;1,3-Benzenedicarboxylic acid, 5-methoxy-, 1-methyl ester;5-methoxy-isophthalic acid monomethyl ester;METHYL 3-(HYDROXYMETHYL)-5-METHOXYBENZOATE | | CAS: | 71590-08-4 | | MF: | C10H10O5 | | MW: | 210.18 | | EINECS: | 200-258-5 | | Product Categories: | | | Mol File: | 71590-08-4.mol |  |
| | METHYL 5-METHOXY-ISOPHTHALATE Chemical Properties |
| Melting point | 165-166 °C | | Boiling point | 383.4±27.0 °C(Predicted) | | density | 1.282±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 3.71±0.10(Predicted) |
| | METHYL 5-METHOXY-ISOPHTHALATE Usage And Synthesis |
| Synthesis | The general procedure for the synthesis of 3-methoxy-5-(methoxycarbonyl)benzoic acid from dimethyl 5-methoxyisophthalate was as follows: dimethyl 5-methoxyisophthalate (5 g, 22.3 mmol) and sodium hydroxide (0.892 g, 22.3 mmol) were dissolved in 50 ml of methanol and the reaction was carried out at reflux at 80 °C overnight. After completion of the reaction, the mixture was cooled to room temperature and the solvent was removed by rotary evaporator. The resulting solid was acidified with hydrochloric acid, the precipitate was collected by filtration, washed with water and dried under vacuum to afford monomethyl 5-methoxyisophthalate as a white solid (4.0 g, 85% yield). | | References | [1] Patent: WO2007/136465, 2007, A2. Location in patent: Page/Page column 35
[2] Synthetic Communications, 2001, vol. 31, # 12, p. 1921 - 1926
[3] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 4, p. 964 - 968
[4] Patent: WO2004/14902, 2004, A2. Location in patent: Page 37-38
[5] Journal of Medicinal Chemistry, 2002, vol. 45, # 19, p. 4188 - 4201 |
| | METHYL 5-METHOXY-ISOPHTHALATE Preparation Products And Raw materials |
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