7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID
| 中文名稱 | 7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID |
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| 中文同義詞 | 7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOICACID |
| 英文名稱 | 7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID |
| 英文同義詞 | 7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID;I-BOP;(5Z)-7-[(1S,4R)-3β-[(1E,3R)-3-Hydroxy-4-(p-iodophenoxy)-1-butenyl]-7-oxabicyclo[2.2.1]heptane-2α-yl]-5-heptenoic acid;(5Z)-7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-Hydroxy-4-(4-iodophenoxy)-1-buten-1-yl]-7-oxabicyclo[2.2.1]hept-2-yl]-5-heptenoic acid;UYFMSCHBODMWON-JCPFAPSOSA-N;I-BOP >=95% (HPLC);5-Heptenoic acid, 7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-hydroxy-4-(4-iodophenoxy)-1-buten-1-yl]-7-oxabicyclo[2.2.1]hept-2-yl]-, (5Z)- |
| CAS號 | 128719-90-4 |
| 分子式 | C23H29IO5 |
| 分子量 | 512.38 |
| EINECS號 | 200-578-6 |
| 相關類別 | |
| Mol文件 | 128719-90-4.mol |
| 結構式 | ![7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID 結構式](CAS/GIF/128719-90-4.gif) |
7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID 性質
| 沸點 | 634.5±55.0 °C(Predicted) |
|---|---|
| 密度 | 1.483±0.06 g/cm3(Predicted) |
| 閃點 | 14℃ |
| 儲存條件 | -20°C |
| 溶解度 | DMF：>50 mg/ml（來自蒎烷 TXA2）； DMSO：>25 mg/ml（來自蒎烷 TXA2）；乙醇：>100 mg/ml（來自蒎烷 TXA2）； PBS（pH 7.2）：3 mg/ml |
| 酸度系數(shù)(pKa) | 4.76±0.10(Predicted) |
| 形態(tài) | 溶液在儲存期間顏色可能會變暗 |
| 顏色 | 無色至淡黃色 |
7-[(1S,2R,3R,4R)-3-[(1E,3R)-3-HYDROXY-4-(4-IODOPHENOXY)-1-BUTENYL]-7-OXABICYCLO[2.2.1]HEPT-2-YL]-5Z-HEPTENOIC ACID 用途與合成方法
I-BOP 是血栓素 A2 受體 (TP) 的激動劑，KD 為 0.61 nM。I-BOP 通過激活血管平滑肌中的 PI3K 通路來促進細胞增殖。I-BOP 劑量依賴性的雙相影響海馬神經(jīng)元中的興奮性突觸后電位 (e.p.s.p.)。