| Company Name: |
Zhejiang Huida Biotech Co., LTD
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| Tel: |
0571-89903022 18679456698 |
| Email: |
zilong@hizyme.com |
| Products Intro: |
Product Name:Galegine hydrochloride
CAS:2368870-39-5
Purity:>=98% Package:10mg
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Galegine hydrochloride
CAS:2368870-39-5
Package:50mg/RMB 13800;25mg/RMB 10600;100mg/RMB 17500
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Galegine xHCl manufacturers
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| | Galegine xHCl Basic information |
| Product Name: | Galegine xHCl | | Synonyms: | Galegine xHCl;Galegine hydrochloride;1-(3-Methylbut-2-en-1-yl)guanidine hydrochloride | | CAS: | 2368870-39-5 | | MF: | C6H14ClN3 | | MW: | 163.65 | | EINECS: | | | Product Categories: | | | Mol File: | 2368870-39-5.mol |  |
| | Galegine xHCl Chemical Properties |
| storage temp. | Store at -20°C | | solubility | |DMSO : 5.2 mg/mL (31.78 mM) | | form | Solid | | color | White to off-white | | Water Solubility | Water : 43.33 mg/mL (264.77 mM) |
| | Galegine xHCl Usage And Synthesis |
| Uses | Galegine hydrochloride, a guanidine derivative, contributes to weight loss in mice. Guanidine hydrochloride is the compound derived from G. officinalis, which gave rise to the biguanides, metformin and phenformin. Galegine hydrochloride activates AMPK in 3T3-L1 adipocytes and L6 myotubes, as well as in the H4IIE rat hepatoma and HEK293 human kidney cell lines. Galegine hydrochloride has antibacterial activity, with minimum inhibitory concentration of 4 mg/L against Staphylococcus aureus strains[1][2]. | | in vivo | Galegine hydrochloride (63 mg/kg; feed; daily for 11 days) produces a significant reduction in body weight[1]. | Animal Model: | Adult male BALB/c mice[1] | | Dosage: | 63 mg/kg | | Administration: | feed; daily for 11 days | | Result: | Produced a significant reduction in body weight. |
| | References | [1] Mooney MH, et al. Mechanisms underlying the metabolic actions of galegine that contribute to weight loss in mice. Br J Pharmacol. 2008 Apr;153(8):1669-77. DOI:10.1038/bjp.2008.37
[2] Coqueiro A, et al. In Vitro Antibacterial Activity of Prenylated Guanidine Alkaloids from Pterogyne nitens and Synthetic Analogues. J Nat Prod. 2014 Aug 22;77(8):1972-5. DOI:10.1021/np500281c |
| | Galegine xHCl Preparation Products And Raw materials |
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