| Company Name: |
ChemeGen
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| Tel: |
18818260767 |
| Email: |
2625930290@qq.com |
| Products Intro: |
Product Name:YM-90K hydrochloride hydrate
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:YM-90K (hydrochloride hydrate)
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| Company Name: |
Neobioscience Co., Ltd.
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| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:YM-90K (hydrochloride hydrate)
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| | YM-90K (hydrochloride hydrate) Basic information |
| | YM-90K (hydrochloride hydrate) Chemical Properties |
| | YM-90K (hydrochloride hydrate) Usage And Synthesis |
| Description | YM-90K is an AMPA receptor antagonist (Ki = 0.084 μM in a radioligand binding assay using rat brain membranes).1 It is selective for AMPA over kainate, NMDA-sensitive glutamate, and strychnine-insensitive glycine receptors (Kis = 2.2, >100, and 37 μM, respectively). Intrastriatal administration of YM-90K inhibits AMPA-induced decreases in choline acetyltransferase (ChAT) activity in rat striatum ex vivo in a dose-dependent manner. It inhibits audiogenic seizures in susceptible DBA/2 mice with a minimum effective dose of 3 mg/kg when administered intraperitoneally. Intravenous infusion of YM-90K (20 mg/kg per hour for 4 hours) reduces infarct size in a rat model of focal cerebral ischemia induced by thrombotic middle cerebral artery occlusion (MCAO) in rats.2WARNING This product is not for human or veterinary use. | | References | [1] J. OHMORI. 6-(1H-Imidazol-1-yl)-7-nitro-2,3(1H,4H)-quinoxalinedione hydrochloride (YM90K) and related compounds: structure-activity relationships for the AMPA-type non-NMDA receptor[J]. Journal of Medicinal Chemistry, 1994, 37 4: 467-475. DOI: 10.1021/jm00030a006
[2] K UMEMURA M N A Shimakura. Neuroprotective effect of a novel AMPA receptor antagonist, YM90K, in rat focal cerebral ischaemia[J]. Brain Research, 1997, 773 1: Pages 61-65. DOI: 10.1016/s0006-8993(97)00894-9 |
| | YM-90K (hydrochloride hydrate) Preparation Products And Raw materials |
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