| Company Name: |
Xiamen Sinopeg Biotech Co., Ltd.
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| Tel: |
400-9189898 17359873007 |
| Email: |
sales@sinopeg.com |
| Products Intro: |
Product Name:Propargyl-PEG2-NHS
CAS:2512228-06-5
Purity:98% Package:1g;10g;100g
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Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester manufacturers
- Propargyl-PEG2-NHS
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2026-07-24
- CAS:2512228-06-5
- Min. Order: 1g
- Purity: 98%
- Supply Ability: 1g/bottle, 10g/bottle, 100g/bottle
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| | Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Basic information |
| | Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Chemical Properties |
| Boiling point | 389.8±50.0 °C(Predicted) | | density | 1.28±0.1 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | form | Solid | | color | White to off-white |
| | Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Usage And Synthesis |
| Uses | Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-NHS ester is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | Biological Activity | Propargyl-PEG2-NHS ester is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. | | IC 50 | PEGs | | References | [1]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-1014. |
| | Propanoic acid, 3-[2-(2-propyn-1-yloxy)ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester Preparation Products And Raw materials |
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