| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:NS4591
CAS:273930-52-2
Package:50mg/RMB 13800;100mg/RMB 17500;25mg/RMB 10600
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2H-Benzimidazol-2-one, 4,5-dichloro-1,3-diethyl-1,3-dihydro- manufacturers
- NS4591
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- $1980.00
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2026-04-21
- CAS:273930-52-2
- Purity:
- Supply Ability: 10g
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| | 2H-Benzimidazol-2-one, 4,5-dichloro-1,3-diethyl-1,3-dihydro- Basic information |
| | 2H-Benzimidazol-2-one, 4,5-dichloro-1,3-diethyl-1,3-dihydro- Chemical Properties |
| Boiling point | 349.8±35.0 °C(Predicted) | | density | 1.320±0.06 g/cm3(Predicted) | | pka | -0.92±0.20(Predicted) |
| | 2H-Benzimidazol-2-one, 4,5-dichloro-1,3-diethyl-1,3-dihydro- Usage And Synthesis |
| Uses | NS4591 is a modulator of calcium-activated potassium channels with activity that enhances small (SK) and intermediate (IK) conductivity. NS4591 doubled IK-mediated currents in whole-cell patch-clamp experiments at a concentration of 45 +/- 6 nM, and doubled SK3-mediated currents at a concentration of 530 +/- 100 nM. NS4591 inhibits the number of action potentials generated by suprathreshold depolarizing pulses in acutely isolated bladder primary afferent neurons. NS4591 also reduced carbakol-induced detrusor ring contraction in the rat bladder, demonstrating sensitivity to apamin[1]. | | References | [1] A positive modulator of K Ca 2 and K Ca 3 channels, 4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo |
| | 2H-Benzimidazol-2-one, 4,5-dichloro-1,3-diethyl-1,3-dihydro- Preparation Products And Raw materials |
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