奈多羅米鈉
| 中文名稱 | 奈多羅米鈉 |
|---|---|
| 中文同義詞 | 奈多羅米鈉;9-乙基-4,6-二氧代-10-丙基-6,9-二氫-4H-吡喃并[3,2-G]喹啉-2,8-二羧酸二鈉鹽;化合物 T19472;化合物 NEDOCROMIL SODIUM;【進(jìn)口原裝】Nedocromil sodium/69049-74-7;【進(jìn)口原裝】Nedocromil sodium/69049-74-7 |
| 英文名稱 | NEDOCROMIL SODIUM |
| 英文同義詞 | NEDOCROMIL DISODIUM SALT;[9-Ethyl-6,9-dihydro-4,6-dioxo-10-propyl-4H-pyrano[3,2-g]quinoline]-2,8-dicarboxylic acid disodium salt;Nedocromil sodium;4H-Pyrano(3,2-G)quinoline-2,8-dicarboxylic acid, 9-ethyl-6,9-dihydro-4,6-dioxo-10-propyl-, disodium salt;Tilade;Unii-et8if4ks1t;Tayled;Tilarin |
| CAS號(hào) | 69049-74-7 |
| 分子式 | C19H18NNaO7 |
| 分子量 | 395.34 |
| EINECS號(hào) | |
| 相關(guān)類別 | 原料藥標(biāo)樣;API |
| Mol文件 | 69049-74-7.mol |
| 結(jié)構(gòu)式 |  |
奈多羅米鈉 性質(zhì)
| 儲(chǔ)存條件 | Inert atmosphere,2-8°C |
|---|---|
| 溶解度 | 在水中的溶解度為20mg/mL，澄清 |
| 形態(tài) | 粉末 |
| 顏色 | 白色到米色到棕色 |
| 水溶解性 | H2O: 20mg/mL, clear |
| InChI | 1S/C19H17NO7.2Na/c1-3-5-9-16-10(13(21)7-12(18(23)24)20(16)4-2)6-11-14(22)8-15(19(25)26)27-17(9)11;;/h6-8H,3-5H2,1-2H3,(H,23,24)(H,25,26);;/q;2*+1/p-2 |
| InChIKey | JQEKDNLKIVGXAU-UHFFFAOYSA-L |
| SMILES | [Na+].[Na+].[n]1(c2c([c](cc1C(=O)[O-])=O)cc3c([o]c(c[c]3=O)C(=O)[O-])c2CCC)CC |
本類藥物包括炎癥細(xì)胞膜穩(wěn)定劑，如色甘酸鈉，奈多羅米鈉以及H1受體阻斷劑如酮替芬，白三烯藥阻斷藥半胱氨酰白三烯等；通過抑制免疫球蛋白E介導(dǎo)的肥大細(xì)胞釋放介質(zhì)和對抑制巨噬細(xì)胞、嗜酸性粒細(xì)胞、單核細(xì)胞等炎癥細(xì)胞的活性發(fā)揮抗過敏作用和輕度的抗炎作用。其平喘作用起效較慢，不宜用于哮喘急性發(fā)作期的治療，臨床上主要用于預(yù)防哮喘的發(fā)作。Nedocromil sodium 抑制多種介質(zhì)的作用或形成，包括組胺，白三烯 C4 (LTC4) 和前列腺素 D2 (PGD2)。
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LTC 4
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PGD 2
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Histamine
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Nedocromil inhibits the release of histamine, LTC 4 , and PGD 2 from mast cells challenged with antigen (with IC 30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively) and with anti-human IgE (IC 30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively).
Nedocromil-treated diabetic mice show significantly improved heart function compared with controls. The contractility and relaxation forces show similar improvements. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice. Nedocromil can significantly improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function.
安全信息
| WGK Germany | 3 |
|---|---|
| 存儲(chǔ)類別 | 11 - 可燃固體 |