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ChemShuttle, Inc.
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0510-83588313-811 18800520310 |
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Product Name:(1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate
CAS:2265886-81-3
Purity:95% Package:5mg;25mg;100mg;500mg;1g;5g;10g;25g;50g;100g;250g;500g;kg…
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https://hanhongsci.com/
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021-54306202 18917919676 |
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info@hanhongsci.com |
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Product Name:dTAG-47
CAS:2265886-81-3
Purity:98+% Package:5mg;25mg;100mg;1g;5g
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| Company Name: |
SuZhou GoodChemTech Co., Ltd
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18136139868; 18136139868 |
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jinlun@goodchemtech.cn |
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Product Name:dTAG-47
CAS:2265886-81-3
Package:1g
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| Company Name: |
TargetMol Chemicals Inc.
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15002134094 |
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marketing@targetmol.cn |
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Product Name:dTAG-47
CAS:2265886-81-3
Package:1removed
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| Company Name: |
R&D Systems, Inc
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18003437475 |
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rdname@qq.com |
| Products Intro: |
Product Name:dTAG-47
CAS:2265886-81-3
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| | (1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate Basic information |
| Product Name: | (1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate | | Synonyms: | (1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate;dTAG-47;(1R)-3-(3,4-Dimethoxyphenyl)-1-[2-[2-[[8-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]amino]octyl]amino]-2-oxoethoxy]phenyl]propyl (2S)-1-[(2S)-1-oxo-2-(3,4,5-trimethoxyphenyl)butyl]-2-piperidinecarboxylate | | CAS: | 2265886-81-3 | | MF: | C59H73N5O14 | | MW: | 1076.25 | | EINECS: | | | Product Categories: | | | Mol File: | 2265886-81-3.mol |  |
| | (1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate Chemical Properties |
| Boiling point | 1157.8±65.0 °C(Predicted) | | density | 1.250±0.06 g/cm3(Predicted) | | solubility | DMSO:107.62(Max Conc. mg/mL);100.0(Max Conc. mM) | | form | Solid | | pka | 10.81±0.40(Predicted) | | color | Light yellow to green yellow |
| | (1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate Usage And Synthesis |
| Description | dTAG-47 is a degrader targeting mutant FKBP12F36V fusion proteins. It comprises a ligand selective for F36V single-point mutated FKBP12, a linker and a cereblon-binding ligand. Application of dTAG-47 induces rapid, reversible and selective degradation of FKBP12F36V fusion proteins in vitro and in vivo. dTAG-47 is generalizable to a range of fusion proteins. It is useful as an alternative to genetic methods for target validation. | | Uses | dTAG-47, heterobifunctional dTAG molecule, targets mutant FKBP12 (FKBP12F36V). FKBP12F36V serves as a degradation tag (dTAG) and is fused to a protein of interest. dTAG-47 can be used for the research of basal-like breast cancers (BBC)[1]. | | storage | Store at -20°C | | References | [1] Hai-Tsang Huang, et al. MELK is not necessary for the proliferation of basal-like breast cancer cells. Elife. 2017 Sep 19;6:e26693. DOI:10.7554/eLife.26693 |
| | (1R)-3-(3,4-dimethoxyphenyl)-1-(2-(2-((8-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)amino)octyl)amino)-2-oxoethoxy)phenyl)propyl (2S)-1-((S)-2-(3,4,5-trimethoxyphenyl)butanoyl)piperidine-2-carboxylate Preparation Products And Raw materials |
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