甲硫氨酸腦啡肽酰胺
| 中文名稱 | 甲硫氨酸腦啡肽酰胺 |
|---|---|
| 中文同義詞 | 甲硫氨酸腦啡肽酰胺;受體激動劑多肽MET-ENKEPHALIN, AMIDE;腦啡肽[MET5]-ENKEPHALIN, AMIDE;601513-1 |
| 英文名稱 | Met-enkephalinamide |
| 英文同義詞 | 5-Methionine-enkephalin amide;L-Methioninamide, L-tyrosylglycylglycyl-L-phenylalanyl-;Lacosamide Impurity 61 |
| CAS號 | 60117-17-1 |
| 分子式 | C27H36N6O6S |
| 分子量 | 572.68 |
| EINECS號 | |
| 相關(guān)類別 | 目錄肽 |
| Mol文件 | 60117-17-1.mol |
| 結(jié)構(gòu)式 |  |
甲硫氨酸腦啡肽酰胺 性質(zhì)
| 熔點 | 142-145 °C |
|---|---|
| 沸點 | 1066.7±65.0 °C(Predicted) |
| 密度 | 1.303±0.06 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 9.97±0.15(Predicted) |
| 序列 | Tyr-Gly-Gly-Phe-Met-NH2 |
[Met5]-Enkephalin, amide 是一種 δ 和 ζ 阿片受體 (opioid receptor) 激動劑。
δ and ζ opioid receptor
[Met5]-Enkephalin at 0.1 nM, 10 nM, and 1 μM significantly reduces the total number of glial cells in culture. [Met5]-Enkephalin, amide acts via δ-opioid receptor to inhibit pelvic nerve-evoked contractions of cat distal colon. [Met5]-enkephalin causes concentration-dependent, reversible inhibition of pelvic nerve-evoked contractions, with an IC 50 value of 2.2 nM. [Met5]enkephalin at a concentration (3 nM) which produces a large inhibition of neurogenic contractions, has no effect on contractions to exogenous acetylcholine.