CHRYSOSPLENOLD manufacturers
- Chrysosplenol D
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- $81.00
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2026-07-27
- CAS:14965-20-9
- Purity: 99.98%
- Supply Ability: 10g
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| | CHRYSOSPLENOLD Basic information |
| Product Name: | CHRYSOSPLENOLD | | Synonyms: | CHRYSOSPLENOLD;2-(3,4-Dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxy-4H-1-benzopyran-4-one;3,6,7-Trimethoxy-3',4',5-trihydroxyflavone;Chrysosplel D;5,3',4'-Trihydroxy-3,6,7-trimethoxyflavone;7-Methylaxillarin;Quercetagetin 3,6,7-triMethyl ether;2-(3,4-dihydroxyphenyl)-5-hydroxy-3,6,7-trimethoxychromen-4-one | | CAS: | 14965-20-9 | | MF: | C18H16O8 | | MW: | 360.31 | | EINECS: | | | Product Categories: | | | Mol File: | 14965-20-9.mol |  |
| | CHRYSOSPLENOLD Chemical Properties |
| Melting point | 236-238 °C | | Boiling point | 645.0±55.0 °C(Predicted) | | density | 1.54±0.1 g/cm3(Predicted) | | storage temp. | 4°C, away from moisture and light | | solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. | | form | powder | | pka | 6.13±0.40(Predicted) | | color | Yellow | | InChI | InChI=1S/C18H16O8/c1-23-12-7-11-13(14(21)17(12)24-2)15(22)18(25-3)16(26-11)8-4-5-9(19)10(20)6-8/h4-7,19-21H,1-3H3 | | InChIKey | BYWLLSQTJBXAPV-UHFFFAOYSA-N | | SMILES | C1(C2=CC=C(O)C(O)=C2)OC2=CC(OC)=C(OC)C(O)=C2C(=O)C=1OC |
| | CHRYSOSPLENOLD Usage And Synthesis |
| Uses | Chrysosplenol D is a methoxy flavonoid that induces ERK1/2-mediated apoptosis in triple negative human breast cancer cells. Chrysosplenol D also exhibits anti-inflammatory and moderate antitrypanosomal activities[1][2][3][4]. | | Definition | ChEBI: 3',4',5-trihydroxy-3,6,7-trimethoxyflavone is a trimethoxyflavone that is the 3,6,7-trimethyl ether derivative of quercetagetin. It has a role as an antineoplastic agent and a metabolite. It is a trihydroxyflavone and a trimethoxyflavone. It is functionally related to a quercetagetin. | | in vivo | Chrysosplenol D (30 μM; 3 d) inhibits MDA-MB-231 tumor growth on chick chorioallantoic membranes[2].
Chrysosplenol D (0.07-0.28 mmol/kg) protects against LPS-induced systemic inflammatory response syndrome (SIRS) in mice[4].
Chrysosplenol D (1-1.5 μmol/cm2) inhibits croton oil-induced ear edema in mice[4]. | | References | [1] Habib ES, et, al. Anti-inflammatory effect of methoxyflavonoids from Chiliadenus montanus (Jasonia Montana) growing in Egypt. Nat Prod Res. 2020 Aug 4;1-5. DOI:10.1080/14786419.2020.1802272
[2] Lang SJ, et, al. Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells. Int J Mol Sci. 2020 Jun 8;21(11):4090. DOI:10.3390/ijms21114090
[3] Skaf J, et, al. Improving anti-trypanosomal activity of alkamides isolated from Achillea fragrantissima. Fitoterapia. 2018 Mar;125:191-198. DOI:10.1016/j.fitote.2017.11.001
[4] Li YJ, et, al. Flavonoids casticin and chrysosplenol D from Artemisia annua L. inhibit inflammation in vitro and in vivo. Toxicol Appl Pharmacol. 2015 Aug 1;286(3):151-8. DOI:10.1016/j.taap.2015.04.005 |
| | CHRYSOSPLENOLD Preparation Products And Raw materials |
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