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Product Name:Mahanine
CAS:28360-49-8
Purity:98% Package:10 g, 25 g, 50 g, 100 g
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MAHANINE manufacturers
- Mahanine
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- $1789.00
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2026-07-15
- CAS:28360-49-8
- Purity:
- Supply Ability: 10g
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| | MAHANINE Basic information |
| Product Name: | MAHANINE | | Synonyms: | MAHANINE;(-)-Mahanin;(3R)-3,11-Dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)pyrano[3,2-a]carbazol-9-ol;Pyrano[3,2-a]carbazol-9-ol, 3,11-dihydro-3,5-dimethyl-3-(4-methyl-3-penten-1-yl)-, (3R)-;(R)-Mahanine | | CAS: | 28360-49-8 | | MF: | C23H25NO2 | | MW: | 347.45 | | EINECS: | | | Product Categories: | | | Mol File: | 28360-49-8.mol |  |
| | MAHANINE Chemical Properties |
| Melting point | 100-loC | | Boiling point | 548.0±50.0 °C(Predicted) | | density | 1.168±0.06 g/cm3(Predicted) | | pka | 10.11±0.40(Predicted) | | form | Solid | | color | Light yellow to brown |
| | MAHANINE Usage And Synthesis |
| Description | This terpene alkaloid, also occurring in the leaves of Murraya koenigii Spreng., is
laevorotatory, having [α]D - 24.4°. Two methyl groups, one phenolic hydroxyl,
an imino group and an unsaturated side chain are present. | | Uses | Mahanine is a carbazole alkaloid with various biological properties. Mahanine is a potent anticancer agent against different types of cancer cells. Mahanine exhibits antileishmanial activity and can be used for Leishmania infection research research. | | in vivo | Mahanine (oral gavage; 20 mg/kg/40 mg/kg; b.w/day; 5 days) results in 89.1±4.1% reductions in parasite burden at 20 mg/kg, and leads to 96.2±0.3% reductions in parasite burden at 40 mg/kg in a well-established acute model to control Leishmaniainfection[1]. | Animal Model: | Balb/c mice with virulent AG83 promastigotes[1] | | Dosage: | 20mg/kg-40 mg/kg | | Administration: | oral gavage; 20mg/kg/40 mg/kg; b.w/day; 5 days | | Result: | Had the potential to clear parasite burdenin vivo.Exhibited almost complete reduction of parasite burden, upregulation of NO/iNOS/ROS/IL-12 and Tcell proliferation in vivo. |
| | IC 50 | Leishmania | | References | Narasimhan, Paradkar, Kelkar.,lnd. J. Chem., 8,473 (1970) |
| | MAHANINE Preparation Products And Raw materials |
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