1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N,2,6,6-tetramethyl-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-3-yl]methyl]-

1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N,2,6,6-tetramethyl-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-3-yl]methyl]- Suppliers list
Company Name: TargetMol  
Tel: 400-821-0310 15002144251
Email: xuexiang.shao@tsbiochem.com
Products Intro: Product Name:TGFβRII-IN-3
CAS:2351149-20-5
Package:50mg;10mg
1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N,2,6,6-tetramethyl-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-3-yl]methyl]- Basic information
Product Name:1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N,2,6,6-tetramethyl-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-3-yl]methyl]-
Synonyms:1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N,2,6,6-tetramethyl-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-3-yl]methyl]-
CAS:2351149-20-5
MF:C27H27F3N2O2
MW:468.51
EINECS:
Product Categories:
Mol File:2351149-20-5.mol
1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N,2,6,6-tetramethyl-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-3-yl]methyl]- Structure
1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N,2,6,6-tetramethyl-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-3-yl]methyl]- Chemical Properties
Melting point 121-122 °C
Boiling point 650.8±55.0 °C(predicted)
density 1.231±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
pka15.60±0.40(predicted)
Safety Information
MSDS Information
1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N,2,6,6-tetramethyl-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-3-yl]methyl]- Usage And Synthesis
UsesTGFβRII-IN-3 (Compound 2r) is a selective inhibitor of the TGFβ type II receptor (TGFβ RII) (IC50 = 4.1 μM). TGFβRII-IN-3 inhibits TGFβ signaling by promoting the proteolytic degradation of TGFβ RII. TGFβRII-IN-3 can block endothelial-to-mesenchymal transition and cell migration. TGFβRII-IN-3 can be used in cancer research[1].
IC 50TGF-βR2: 4.1 μM (IC50)
References[1] Lngle D, et al.Expanding the Chemical Space of Transforming Growth Factor-β (TGFβ) Receptor Type II Degraders with 3,4-Disubstituted Indole Derivatives. ACS Pharmacol Transl Sci. 2024 Mar 21;7(4):1069-1085. DOI:10.1021/acsptsci.3c00371
1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N,2,6,6-tetramethyl-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-3-yl]methyl]- Preparation Products And Raw materials
Tag:1H-Indole-3-carboxamide, 4,5,6,7-tetrahydro-N,2,6,6-tetramethyl-4-oxo-N-[[4′-(trifluoromethyl)[1,1′-biphenyl]-3-yl]methyl]-(2351149-20-5) Related Product Information