Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione

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Products Intro: Product Name:Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS:37538-68-4
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
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Products Intro: Product Name:2,4-Dihydroxypyrido[3,2-d]pyrimidine
CAS:37538-68-4
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Products Intro: Product Name:Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS:37538-68-4
Purity:99.0% Package:1KG;1USD
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Products Intro: Product Name:Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione
CAS:37538-68-4
Purity:95%

Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione manufacturers
Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione Basic information
Product Name:Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione
Synonyms:Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione;1H,2H,3H,4H-pyrido[3,2-d]pyriMidine-2,4-dione;2,4-Dihydroxypyrido[3,2-d]pyriMidine;1H,3H-Pyrido[3,2-d]pyriMidine-2,4-dione;1H-Pyrido[3,2-d]pyrimidine-2,4-dione;1H,3H-pyrido[3,2-d]pyrimidine-2,4-dione - [AC78393]
CAS:37538-68-4
MF:C7H5N3O2
MW:163.13
EINECS:
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Mol File:37538-68-4.mol
Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione Structure
Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione Chemical Properties
Melting point 320 °C
density 1.424±0.06 g/cm3(Predicted)
pka9.27±0.20(Predicted)
Safety Information
HS Code 2933998090
MSDS Information
Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione Usage And Synthesis
Uses2,4-Dihydroxypyrido[3,2-d]pyrimidine is used as a reagent in the synthesis of diaminoquinazolines as antitubercular agents. 2,4-Dihydroxypyrido[3,2-d]pyrimidine may also be used as a potential histamine H4 receptor antagonist.
Synthesis
3-Amino-2-pyridinecarboxylic acid

1462-86-8

Urea

57-13-6

Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione

37538-68-4

(1) 4 g of 3-aminopyridine-2-carboxylic acid (raw material A3) was mixed with 20 g of urea and heated and refluxed at 200°C for 5 h. After the reaction was completed, intermediate B3 was obtained in 27% yield. The reaction equation was as follows:

References[1] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 9, p. 2663 - 2670
[2] Patent: CN106083742, 2016, A. Location in patent: Paragraph 0185; 0186; 0187
[3] Journal of the Chemical Society, 1956, p. 1045,1053
Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione Preparation Products And Raw materials
Raw materials3-Amino-2-pyridinecarboxylic acid-->Urea
Preparation ProductsPyrido[3,2-d]pyrimidin-4(1H)-one (9CI)-->2,4-Dichloropyrido[3,2-d]pyrimidine
Tag:Pyrido[3,2-d]pyrimidine-2,4(1H,3H)-dione(37538-68-4) Related Product Information
pyrido[3,4-b]pyrazin-5-ylmethanamine pyrido[4,3-d]pyrimidin-4-amine Pyrido[4,3-d]pyriMidine-2,4(1H,3H)-dione PYRIDO[3,4-D]PYRIMIDINE-2,4(1H,3H)-DIONE Pyrido[4,3-d]pyrimidine-2,4-diamine PYRIDO[3,2-D]PYRIMIDIN-4-AMINE Pyrido[3,2-d]pyrimidine-2,4-diamine pyrido[3,4-b]pyrazine-5-carboxylic acid pyrido[3,4-b]pyrazine-5-carbonitrile pyrido[3,4-d]pyrimidine-2,4-diamine pyrido[3,2-d]pyrimidin-2-amine PYRIDO[2,3-D]PYRIMIDINE-2,4(1H,3H)-DIONE