- 4-BROMO-2-IODOANILINE
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- $1.10
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2025-11-18
- CAS:66416-72-6
- Min. Order: 1g
- Purity: 99.00%
- Supply Ability: 100 Tons Min
- 4-BROMO-2-IODOANILINE
-
- $1.00
-
2019-12-26
- CAS:66416-72-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 1000KGS
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| | 4-BROMO-2-IODOANILINE Basic information |
| | 4-BROMO-2-IODOANILINE Chemical Properties |
| Melting point | 69-72 °C(lit.) | | Boiling point | 297.9±30.0 °C(Predicted) | | density | 2.292±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | soluble in Methanol | | form | Powder | | pka | 1.83±0.10(Predicted) | | color | Gray to purple | | InChI | InChI=1S/C6H5BrIN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2 | | InChIKey | HHTYEQWCHQEJNV-UHFFFAOYSA-N | | SMILES | C1(N)=CC=C(Br)C=C1I | | CAS DataBase Reference | 66416-72-6(CAS DataBase Reference) |
| Hazard Codes | T,N,Xi | | Risk Statements | 25-37/38-41-51/53 | | Safety Statements | 26-36/37/39-45-61 | | RIDADR | UN 2811 6.1/PG 3 | | WGK Germany | 3 | | Hazard Note | Irritant | | HazardClass | 6.1 | | PackingGroup | Ⅲ | | HS Code | 29214200 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Oral
Aquatic Chronic 2
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 4-BROMO-2-IODOANILINE Usage And Synthesis |
| Chemical Properties | Grey to purple powder | | Uses | 4-Bromo-2-iodoaniline may be used in the following:
- Preparation of quinolone derivatives.
- Synthesis of a resin-bound sulfonamide, which was used as a starting material for the preparation of 2,3,5-trisubstituted indoles.
| | General Description | 4-Bromo-2-iodoaniline is a 2-iodoaniline derivative. It can be prepared by reacting 4-bromoaniline with iodine. | | Synthesis | General procedure: Iodination of aryl amines was carried out under solvent-free conditions. DBDABCODCI (0.5 mmol) was co-milled with 4-bromoaniline (1 mmol) in a porcelain mortar at room temperature. The reaction process was monitored by thin layer chromatography (TLC). Upon completion of the reaction, ethyl acetate was added to the mixture and subsequently filtered. The organic layer was washed with 5% aqueous sodium thiosulfate and dried with anhydrous magnesium sulfate. The solvent was removed under reduced pressure and the resulting crude product was purified by column chromatography, the eluent being a solvent mixture of ethyl acetate and hexane. The purified product was characterized by melting point determination and 1H NMR spectroscopy. | | References | [1] Bulletin of the Chemical Society of Japan, 1988, vol. 61, # 2, p. 600 - 602
[2] Bulletin of the Chemical Society of Ethiopia, 2015, vol. 29, # 1, p. 157 - 162
[3] RSC Advances, 2018, vol. 8, # 54, p. 30761 - 30776
[4] Synthesis, 2008, # 13, p. 2039 - 2044
[5] Patent: US9212182, 2015, B2. Location in patent: Page/Page column 198; 199 |
| | 4-BROMO-2-IODOANILINE Preparation Products And Raw materials |
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