LY 266097 hydrochloride

LY 266097 hydrochloride Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354; +17819995354
Email: marketing@targetmol.com
Products Intro: Product Name:LY266097 hydrochloride
CAS:172895-39-5
Purity:99.63% Package:5mg;69USD|10mg;105USD|25mg;178USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel:
Email: tp@aladdinsci.com
Products Intro: Product Name:LY 266097 hydrochloride
CAS:172895-39-5
Purity:>=99%(HPLC) Package:$142.9/5mg;$211.9/10mg;$477.9/25mg;$858.9/50mg;$1545.9/100mg;Bulk package Remarks:99%(HPLC)
Company Name: BOC Sciences  
Tel: 1-631-485-4226; 16314854226
Email: info@bocsci.com
Products Intro: Product Name:LY 266097 hydrochloride
CAS:172895-39-5
Purity:>=99% by HPLC Remarks:Reach out to us for more information about custom solutions.
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
Email: info@emmx.com
Products Intro: Product Name:LY 266097 hydrochloride
CAS:172895-39-5
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
Company Name: Shanghai YuanYe Biotechnology Co., Ltd.  
Tel: 021-61312847; 18021002903
Email: 3008007409@qq.com
Products Intro: Product Name:LY 266097 hydrochloride
CAS:172895-39-5
Purity:>=99%(HPLC) Package:100mg Remarks:S55538

LY 266097 hydrochloride manufacturers
LY 266097 hydrochloride Basic information
Product Name:LY 266097 hydrochloride
Synonyms:LY 266097 hydrochloride;LY 266097;LY266097;LY266097 >=98% (HPLC), powder;LY-266097 hydrochloride,LY266097 hydrochloride;LY266097 hydrochloride, 10 mM in DMSO;1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride
CAS:172895-39-5
MF:C21H24Cl2N2O2
MW:407.34
EINECS:
Product Categories:
Mol File:172895-39-5.mol
LY 266097 hydrochloride Structure
LY 266097 hydrochloride Chemical Properties
storage temp. 2-8°C
solubility DMSO: ≥20mg/mL
form powder
color white to tan
InChI1S/C21H23ClN2O2.ClH/c1-12-4-6-16-15(10-12)14-8-9-23-17(20(14)24-16)11-13-5-7-18(25-2)21(26-3)19(13)22;/h4-7,10,17,23-24H,8-9,11H2,1-3H3;1H
InChIKeyKPXKZZURYAXZQE-UHFFFAOYSA-N
SMILESCl.COc1ccc(CC2NCCc3c2[nH]c4ccc(C)cc34)c(Cl)c1OC
Safety Information
WGK Germany 3
Storage Class11 - Combustible Solids
Hazard ClassificationsEye Irrit. 2
MSDS Information
LY 266097 hydrochloride Usage And Synthesis
UsesLY 266097 Hydrochloride is a potent and selective serotonin 2B (5HT2B) contractile receptor.
Biological ActivityLY266097 is a selective 5HT-2B antagonist with a pKI of 9.7 for the human cloned 5-HT2B receptor and a 100-fold greater selectivity for 5-HT2B than the human 5-HT2C and 5-HT2A.
in vivo

LY266097 (0.6 mg/kg for 2-day administration) rescues Escitalopram-induced decrease in dopamine (DA) [1].
The administration of LY266097 alone or its addition on the last 3 days of a 14-day Escitalopram regimen increases pyramidal neuron firing and burst activity[1].

Animal Model:Male Sprague-Dawley rats weighing 250-350g[1]
Dosage:0.6mg/kg
Administration:Administered i.p. alone or concomitantly with Escitalopram (2mg/kg) for 2 days
Result:Short-term administration (0.6mg/kg/day for 2 days; i.p.) alone had no effect on these parameters, its co-administration counteracted the inhibitory effect of escitalopram on the firing activity of DA neurons, resulting in a recovery to control level.
IC 505-HT2B Receptor: 9.8 (pKi); 5-HT2A Receptor: 7.7 (pKi); 5-HT2C Receptor: 7.6 (pKi)
storageStore at +4°C
LY 266097 hydrochloride Preparation Products And Raw materials
Tag:LY 266097 hydrochloride(172895-39-5) Related Product Information