| Company Name: |
Dalian Meilun Biotech Co., Ltd.
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| Tel: |
0411-62910999 13889544652 |
| Email: |
sales@meilune.com |
| Products Intro: |
Product Name:CAY-10506 CAS:292615-75-9 Purity:>98%,BR Package:1MG Remarks:MB6150
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| Company Name: |
BOC Sciences
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| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CAY10506 CAS:292615-75-9 Purity:98% Package:1G;10G;100G Remarks:Peroxisome proliferator-activated receptor gamma (PPARγ), also known as the glitazone receptor, or NR1C3, is a type II nuclear receptor that in humans is encoded by the PPARG gene. CAY10506 is a PPARγ
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CAY10506 manufacturers
- CAY10506
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- $1230.00
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2026-05-11
- CAS:292615-75-9
- Purity:
- Supply Ability: 10g
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| | CAY10506 Basic information |
| Product Name: | CAY10506 | | Synonyms: | CAY10506;CAY10506 Exclusive;N-[2-[4-[(2,4-dioxo-1,3-thiazolidin-5-yl)methyl]phenoxy]ethyl]-5-(dithiolan-3-yl)pentanamide;1,2-Dithiolane-3-pentanamide, N-[2-[4-[(2,4-dioxo-5-thiazolidinyl)methyl]phenoxy]ethyl]- | | CAS: | 292615-75-9 | | MF: | C20H26N2O4S3 | | MW: | 454.62 | | EINECS: | | | Product Categories: | | | Mol File: | 292615-75-9.mol |  |
| | CAY10506 Chemical Properties |
| Boiling point | 722.0±40.0 °C(Predicted) | | density | 1.305±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 5 mg/ml; DMSO: 5 mg/ml; DMSO:PBS(pH 7.2) (1:5): 0.15 mg/ml; Ethanol: 3 mg/ml | | pka | 6.35±0.50(Predicted) |
| | CAY10506 Usage And Synthesis |
| Description | Anti-diabetic drugs of the thiazolidinedione (TZD) structural class as well as α-lipoic acid activate peroxisome proliferator-activated receptor γ (PPARγ), a nuclear transcription factor that controls glucose metabolism and lipid homeostasis. CAY10506 is a hybrid lipoic acid-TZD derivative that transactivates human PPARγ with an EC50 value of 10 μM. | | Uses | CAY10506 is a PPARγ ligand that can induce cell death and ROS production in a PPARγ-dependent manner in vitro. CAY10506 exhibits radiosensitizing effects, enhancing γ-radiations-induced apoptosis and caspase-3-mediated poly (ADP-ribose) polymerase (PARP) cleavage. CAY10506 can be used in cancer research[1]. | | References | [1] Han EJ, et al. Combined treatment with peroxisome proliferator-activated receptor (PPAR) gamma ligands and gamma radiation induces apoptosis by PPARγ-independent up-regulation of reactive oxygen species-induced deoxyribonucleic acid damage signals in non-small cell lung cancer cells. Int J Radiat Oncol Biol Phys. 2013 Apr 1;85(5):e239-48. DOI:10.1016/j.ijrobp.2012.11.040 |
| | CAY10506 Preparation Products And Raw materials |
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