| Company Name: |
VDM Biochemicals
|
| Tel: |
0330-2528181 |
| Email: |
sales@vdmbio.com |
| Products Intro: |
Product Name:GSK-3 Inhibitor X
CAS:740841-15-0
Purity:>=97%
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| Company Name: |
Shandong Xiya Chemical Co., Ltd
|
| Tel: |
13355009207 13355009207 |
| Email: |
3007715519@qq.com |
| Products Intro: |
CAS:740841-15-0
Purity:>=95.0% Package:1g
|
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| | GSK-3 Inhibitor X Basic information |
| | GSK-3 Inhibitor X Chemical Properties |
| storage temp. | +2C to +8C | | solubility | DMF: 10 mg/ml; DMSO: 10 mg/ml | | form | Dark purple solid | | color | dark purple | | Sensitive | Light Sensitive |
| WGK Germany | WGK 1 | | Storage Class | 11 - Combustible Solids |
| | GSK-3 Inhibitor X Usage And Synthesis |
| Uses | (E/Z)-BIO-acetoxime (GSK-3 Inhibitor X) is a potent and selective GSK-3α/β inhibitor, with an IC50 of 10 nM. (E/Z)-BIO-acetoxime shows more than 200-flod selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B (IC50=2.4, 4.3, 63 μM)[1]. | | General Description | An acetoxime analog of BIO, GSK-3 Inhibitor IX (Cat. No. 361550) that exhibits greater selectivity for GSK-3α/β (IC50 = 10 nM) over Cdk5/p25, Cdk2/cyclin A, and Cdk1/cyclin B (IC50 = 2.4 μM, 4.3 μM, and 63 μM, respectively). A weak inhibitor of Cdk4/cyclin D1 and many other non-related kinases (IC50 ≥ 10 μM). Yields BIO (Cat. No. 361550) upon hydrolysis. | | Biochem/physiol Actions | Product does not compete with ATP. | | IC 50 | GSK-3α: 10 nM (IC50); GSK-3β: 10 nM (IC50); Cdk5/p25: 2.4 μM (IC50); CDK2/cyclinA: 4.3 μM (IC50); CDK1/cyclinB: 63 μM (IC50) | | References | [1] Meijer L, et, al. GSK-3-selective inhibitors derived from Tyrian purple indirubins. Chem Biol. 2003 Dec;10(12):1255-66. DOI:10.1016/j.chembiol.2003.11.010 |
| | GSK-3 Inhibitor X Preparation Products And Raw materials |
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