D159687
| 中文名稱 | D159687 |
|---|---|
| 中文同義詞 | 1-(4-((3'-氯-6-甲氧基-[1,1'-聯(lián)苯]-3-基)甲基)苯基)脲;化合物D 159687;化合物D 159687,10 MM DMSO 溶液 |
| 英文名稱 | 1-(4-((3'-Chloro-6-Methoxy-[1,1'-biphenyl]-3-yl)Methyl)phenyl)urea |
| 英文同義詞 | D159687;1-(4-((3'-chloro-6-methoxybiphenyl-3-yl)methyl)phenyl)urea;D159687; D-159687; D 159687;Urea, N-[4-[(3'-chloro-6-methoxy[1,1'-biphenyl]-3-yl)methyl]phenyl]-;[4-[[3-(3-chlorophenyl)-4-methoxyphenyl]methyl]phenyl]urea;Inhibitor,inhibit,D159687,D-159687,Phosphodiesterase (PDE);1-(4-((3'-Chloro-6-methoxy-[1,1'-biphenyl]-3-yl)methyl)phenyl)urea;4-({3'-chloro-6-methoxy-[1,1'-biphenyl]-3-yl}methyl)phenyl]urea |
| CAS號 | 1155877-97-6 |
| 分子式 | C21H19ClN2O2 |
| 分子量 | 366.84 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 1155877-97-6.mol |
| 結(jié)構(gòu)式 |  |
D159687 性質(zhì)
| 沸點 | 502.0±50.0 °C(Predicted) |
|---|---|
| 密度 | 1.263±0.06 g/cm3(Predicted) |
| 儲存條件 | Sealed in dry,Room Temperature |
| 溶解度 | 二甲基亞砜：150 mg/mL（408.90 mM） |
| 酸度系數(shù)(pKa) | 14.48±0.50(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| InChI | 1S/C21H19ClN2O2/c1-26-20-10-7-15(12-19(20)16-3-2-4-17(22)13-16)11-14-5-8-18(9-6-14)24-21(23)25/h2-10,12-13H,11H2,1H3,(H3,23,24,25) |
| InChIKey | RJJLUTWHJUDZFP-UHFFFAOYSA-N |
| SMILES | Clc1cc(ccc1)c2c(ccc(c2)Cc3ccc(cc3)NC(=O)N)OC |
D159687 是一種選擇性 PDE4D 抑制劑。
PDE4D
D159687 (1 μM, 0-24?hours) induces a transient increase in CREB phosphorylation which peaked at 6?hours after treatment.
D159687 (0.01-1 μM, 6 hours) causes optimal CREB phosphorylation at 1?μM.
Western Blot Analysis
| Cell Line: | HT-22 (mouse hippocampal cell line) |
| Concentration: | 1 μM |
| Incubation Time: | 0, 1, 3, 6, 12, 24?hours |
| Result: | Induced a transient increase in CREB phosphorylation which peaked at 6?hours after treatment. |
Western Blot Analysis
| Cell Line: | HT-22 (mouse hippocampal cell line) |
| Concentration: | 0.01 μM, 0.1 μM, 1 μM |
| Incubation Time: | 6 hours |
| Result: | CREB phosphorylation was optimal at 1?μM. |
D159687 (0.05-5 mg/kg; oral daily for a week) shows a potential recruitment or enhancement of synaptic function with increased task difficulty in female Cynomolgus macaques.
| Animal Model: | Female Cynomolgus macaques (4–6 year old) |
| Dosage: | 0.05, 0.5, 5 mg/kg |
| Administration: | Oral daily for a week |
| Result: | A potential recruitment or enhancement of synaptic function with increased task difficulty. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-15444 | D159687 D159687 | 1155877-97-6 | 1 mg | 273元 |
| 2026/06/05 | HY-15444 | D159687 D159687 | 1155877-97-6 | 5mg | 600元 |