5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽
| 中文名稱 | 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽 |
|---|---|
| 中文同義詞 | 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽;阿卡地新磷酸鹽?, >98%;阿卡地新磷酸鹽;化合物 T14149 |
| 英文名稱 | AICAR (phosphate) |
| 英文同義詞 | AICAR (phosphate);5-Amino-1-ribosylimidazole-4-carboxamide phosphate;AICAR (Acadesine) phosphate;AICAR phosphate, >98%;AICA Riboside phosphate);AICAR phosphate (Acadesine phosphate;Acadesine phosphate;ACADESINE PHOSPHATE;AICA RIBOSIDE PHOSPHATE |
| CAS號 | 681006-28-0 |
| 分子式 | C9H17N4O9P |
| 分子量 | 356.23 |
| EINECS號 | |
| 相關(guān)類別 | 對照品 |
| Mol文件 | 681006-28-0.mol |
| 結(jié)構(gòu)式 | ![]() |
5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽 性質(zhì)
| 儲存條件 | Store at -20°C |
|---|---|
| 溶解度 | 溶于二甲基亞砜 |
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
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AMPK
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Autophagy
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Mitophagy
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HepG2 cells are treated with various concentrations of AICAR (0.1-1.0 mM) for 12, 24, and 48 h, respectively. The expression level of IR-β significantly decreases with 0.25, 0.5, and 1.0 mM of AICAR at 48 h to 50%, 53%, and 46% of the control, respectively.
Fourteen-week-old male, lean (L; 31.3 g body wt) wild-type andob/ob (O; 59.6 g body wt) mice are injected with the AMP-activated kinase (AMPK) activator AICAR (A) at 0.5 mg*g body wt -1 *day -1 or saline control (C) for 14 days. At 24 h after the last injection (including a 12-h fast), all mice are killed, and the plantar flexor complex muscle (gastrocnemius, soleus, and plantaris) is excised for analysis. Muscle mass is lower in OC (159±12 mg) than LC, LA, and OA (176±10, 178±9, and 166±16 mg, respectively) mice, independent of a body weight change. The kidney weight is significantly higher in the untreated group when compared with both the exercise and AICAR (0.5 mg/g body wt) groups. The heart weight is higher in the exercise group than in the other groups, whereas the liver weight is significantly higher in the AICAR-treated group when compared with the exercise and untreated groups.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-13417AR | 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽 AICAR phosphate (Standard) | 681006-28-0 | 5 mg | 300元 |
| 2026/06/05 | HY-13417AR | 5-氨基-1-核糖基咪唑-4-甲酰胺磷酸鹽 AICAR phosphate (Standard) | 681006-28-0 | 10 mg | 470元 |
