BX 430
| 中文名稱 | BX 430 |
|---|---|
| 中文同義詞 | 化合物BX430;1-(2,6-二溴-4-異丙基苯基)-3-(吡啶-3-基)脲;BX 430,P2X4變構(gòu)拮抗劑;化合物BX430,10 MM DMSO 溶液 |
| 英文名稱 | BX 430 |
| 英文同義詞 | BX 430;N-[2,6-Dibromo-4-(1-methylethyl)phenyl]-N'-(3-pyridinyl)urea;Urea, N-[2,6-dibromo-4-(1-methylethyl)phenyl]-N'-3-pyridinyl-;1-(2,6-Dibromo-4-isopropylphenyl)-3-(pyridin-3-yl)urea;P2X Receptor,Ca channels,BX430,chronic,channels,species,P2XRs,Inhibitor,disease,Ca2+ channels,BX 430,cardiovascular,P2X4,receptor,specificity,inhibit,Calcium Channel,human,pain,BX-430;BX430, 10 mM in DMSO |
| CAS號(hào) | 688309-70-8 |
| 分子式 | C15H15Br2N3O |
| 分子量 | 413.11 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 688309-70-8.mol |
| 結(jié)構(gòu)式 |  |
BX 430 性質(zhì)
| 熔點(diǎn) | 164-168°C |
|---|---|
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | 可溶于DMSO（少許）、甲醇（少許） |
| 形態(tài) | 固體 |
| 顏色 | 白色 |
| InChI | 1S/C15H15Br2N3O/c1-9(2)10-6-12(16)14(13(17)7-10)20-15(21)19-11-4-3-5-18-8-11/h3-9H,1-2H3,(H2,19,20,21) |
| InChIKey | JFNKIJKRXKPQCC-UHFFFAOYSA-N |
| SMILES | BrC1=CC(C(C)C)=CC(Br)=C1NC(NC2=CC=CN=C2)=O |
BX430 是一種有效的、選擇性的、非競爭性 human P2X4 receptor 通道的變構(gòu)拮抗劑，IC50值為0.54 μM。BX430 是對(duì)斑馬魚P2X4有效的拮抗劑，但對(duì)大鼠和小鼠P2X4直系同源物沒有作用。BX430 可用于慢性疼痛和心血管疾病。
| Target | Value |
|
hP2X4
(Cell-free assay) | 0.54 μM |
BX430 has virtually no functional impact on all other P2X subtypes, namely, P2X1-P2X3, P2X5, and P2X7, at 10-100 times its IC
50
.
BX430 is a potent antagonist of zebrafish P2X4 but has no effect on rat and mouse P2X4 orthologs.
Human P2X4-expressing cells treated with thapsigargin plus BX430 shows a significant reduction in the intracellular calcium rise evoked by ATP.
BX430 (5 μM) markedly reduces the amplitude of ATP-evoked intracellular calcium responses in THP-1 cells.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 危險(xiǎn)性類別 | 急性毒性 類別4 經(jīng)口 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | S0758 | BX 430 BX430 | 688309-70-8 | 5mg | 1370.62元 |
| 2026/07/06 | S0758 | BX 430 BX430 | 688309-70-8 | 25mg | 4170.59元 |