Propargyl-PEG2-Tos manufacturers
- Propargyl-PEG2-Tos
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2025-06-07
- CAS:145916-41-2
- Min. Order: 5g
- Purity: >98.00%
- Supply Ability: 5g
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| | Propargyl-PEG2-Tos Basic information |
| Product Name: | Propargyl-PEG2-Tos | | Synonyms: | Propargyl-PEG2-Tos;2-(prop-2-yn-1-yloxy)ethyl 4-methylbenzenesulfonate;Ethanol, 2-(2-propyn-1-yloxy)-, 1-(4-methylbenzenesulfonate);2-(2-Propyn-1-yloxy)ethyl 4-Methylbenzenesulfonate;Prop-2-yn-1-yloxy)ethyl 4-methylbenzenesulfonate;Propargyl-PEG1-Tos;2-(Propargyloxy)ethyl tosylate | | CAS: | 145916-41-2 | | MF: | C12H14O4S | | MW: | 254.3 | | EINECS: | | | Product Categories: | | | Mol File: | 145916-41-2.mol |  |
| | Propargyl-PEG2-Tos Chemical Properties |
| storage temp. | 2-8°C, stored under nitrogen | | form | Liquid | | color | Colorless to light yellow |
| | Propargyl-PEG2-Tos Usage And Synthesis |
| Description | Propargyl-PEG2-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. | | Uses | Propargyl-PEG2-Tos is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Propargyl-PEG2-Tos is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | | IC 50 | PEGs | | References | [1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005 |
| | Propargyl-PEG2-Tos Preparation Products And Raw materials |
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