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OSW-1

OSW-1

中文名稱OSW-1
中文同義詞化合物 T21251;(3BETA,16BETA)-16-[[2-O-乙?;?3-O-[2-O-(4-甲氧基苯甲?;?-BETA-D-吡喃木糖基]-ALPHA-L-吡喃阿拉伯糖基]氧基]-3,17-二羥基膽甾-5-烯-22-酮;化合物 OSW-1;OSW-1 #天然產(chǎn)物 HY-101213;OSW-1 #天然產(chǎn)物 HY-101213
英文名稱OSW-1
英文同義詞OSW-1;16beta-[2-O-Acetyl-3-O-[2-O-(4-Methoxybenzoyl)-beta-D-xylopyranosyl)-alpha-L-arabinopyranosyloxy]-3b;Cholest-5-en-22-one, 16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3β,16β)-;OSW-1, >90% (Orsaponin);Cholest-5-en-22-one,16-[[2-O-acetyl-3-O-[2-O-(4-methoxybenzoyl)-b-D-xylopyranosyl]-a-L-arabinopyranosyl]oxy]-3,17-dihydroxy-, (3b,16b)-;Orsaponin;OSW-1 (Orsaponin);(3β,16β)-16-[[2-O-Acetyl-3-O-[2-O-(4-methoxybenzoyl)-β-D-xylopyranosyl]-α-L-arabinopyranosyl]oxy]-3,17-dihydroxycholest-5-en-22-one
CAS號(hào)145075-81-6
分子式C47H68O15
分子量873.03
EINECS號(hào)
相關(guān)類別
Mol文件145075-81-6.mol
結(jié)構(gòu)式OSW-1 結(jié)構(gòu)式

OSW-1 性質(zhì)

沸點(diǎn)932.5±65.0 °C(Predicted)
密度1.31±0.1 g/cm3(Predicted)
儲(chǔ)存條件Hygroscopic, Refrigerator, under inert atmosphere
溶解度可溶于氯仿(微量)、甲醇(微量)、吡啶(微量)
酸度系數(shù)(pKa)12.65±0.70(Predicted)
形態(tài)固體
顏色白色至類白色
InChIKeyMPXTYZZFIJTPPA-GMJJYARYNA-N

OSW-1 用途與合成方法

OSW-1 是從虎眼萬(wàn)年青中分離出來(lái)的,osterol-binding protein (OSBP) 和 OSBP-elated protein 4 (ORP4) 的特異性拮抗劑,其在人類腫瘤細(xì)胞系中的 GI50 值為納摩爾級(jí)別。

OSBP/ORP4.

OSW-1 has a strong inhibitory effect on colon carcinoma cells with low cytotoxicity on normal cells. The anti-proliferative effects of OSW-1 on SW480 and LoVo colon carcinoma cells are characterized by measuring cell viability using the CCK8 assay, and compared the results with other clinical anticancer agents. SW480 and LoVo cell lines are derived from a Dukes' stage B colon carcinoma and a colon carcinoma metastatic nodule, which represent non-metastatic and metastatic carcinomas, respectively. OSW-1 exhibits not only extremely strong anticancer activity in SW480 and LoVo cell lines with an IC 50 of nanomolar concentration, but is also more potent than other anticancer agents by 10-100 times, with a lower cytotoxic effect on normal epithelial cells. These results indicate that OSW-1 has a powerful anticancer effect, but lower cytotoxic effect on normal cells.

To ascertain whether or not OSW-1 is as effective in vivo, a nude mouse model inoculated by LoVo cells is adopted, in which OSW-1 treatment is performed when tumors became palpable. The results show that the size of tumors in treated mice is smaller on average than control mice. The significant difference is observed from the 15-17 th day following treatment, and this difference is gradually increased until the animals are sacrificed. Compared with the control group, the tumor weight of the OSW-1-treated group significantly decreases (P<0.05). Additionally, no apparent side effects are observed in OSW-1-treated mice. These results demonstrate that OSW-1 has powerful effects on suppressing colon tumor growth without significant side effects in vivo.

安全信息

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/06/05HY-101213OSW-1
OSW-1
145075-81-6500 μg5580元
2025/02/08HY-101213OSW-1
OSW-1
145075-81-61mg3800元

OSW-1 上下游產(chǎn)品信息

"OSW-1"相關(guān)產(chǎn)品信息
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