- NS-1619
-
- $30.00
-
2026-04-22
- CAS:153587-01-0
- Purity: 98.00%
- Supply Ability: 10g
- NS 1619
-
- $9.80
-
2020-01-14
- CAS:153587-01-0
- Min. Order: 1g
- Purity: ≥99%
- Supply Ability: 100kg
|
| | NS 1619 Basic information |
| Product Name: | NS 1619 | | Synonyms: | NS 1619;NS 1619 (1,3-DIHYDRO-1-(2-HYDROXY-5-(TRI FLUOROMETHYL)PHEN;1,3-DIHYDRO-1-[2-HYDROXY-5-(TRIFLUOROMETHYL)PHENYL]-5-(TRIFLUOROMETHYL)-2H-BENZIMIDAZOL-2-ONE;1-(2-hydroxy-5-(trifluoroMethyl)phenyl)-5-(trifluoroMethyl)-1H-b;NS1619;NS 1619;NS 161;2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-;1-[2-Hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-1,3-dihydro-2H-benzimidazol-2-one | | CAS: | 153587-01-0 | | MF: | C15H8F6N2O2 | | MW: | 362.23 | | EINECS: | | | Product Categories: | API | | Mol File: | 153587-01-0.mol |  |
| | NS 1619 Chemical Properties |
| density | 1.563±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,2-8°C | | solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47 mg/mL | | pka | 8.32±0.48(Predicted) | | form | solid | | color | white | | Water Solubility | 45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 0.47mg/mL
ethanol: 26.6mg/mL
0.1 M NaOH: 5.2mg/mL
DMSO: 5.3mg/mL
H2O: insoluble | | InChI | InChI=1S/C15H8F6N2O2/c16-14(17,18)7-1-3-10-9(5-7)22-13(25)23(10)11-6-8(15(19,20)21)2-4-12(11)24/h1-6,24H,(H,22,25) | | InChIKey | YLFMCMWKHSDUCT-UHFFFAOYSA-N | | SMILES | C1(=O)N(C2=CC(C(F)(F)F)=CC=C2O)C2=CC=C(C(F)(F)F)C=C2N1 |
| WGK Germany | 3 | | Storage Class | 11 - Combustible Solids |
| | NS 1619 Usage And Synthesis |
| Uses | NS 1619 is a large conductance calcium-activated potassium channels (BKCa) activator and has been shown to induce precondition in the heart. | | Definition | ChEBI: A member of the class of benzimidazoles that is 1,3-dihydro-2H-benzimidazol-2-one in which the hydrogens at positions 1 and 5 are replaced are replaced by 2-hydroxy-5-(trifluoromethyl)phenyl and trifluoromethyl groups, respectively. It i
an opener/activator of the large-conductance calcium-activated potassium channel (Bkca). | | Biochem/physiol Actions | NS 1619 is a selective large conductance Ca2+-activated K+-channel activator. The compound is known for its vasodilating and anti-proliferative properties. It is studied that NS 1619 can protect cardiac muscle against ischemia and reperfusion injury. | | in vivo | Opening of KCa channels with NS-1619 (1 mg/kg; i.p.) can delay protection in mouse hearts[3]. | Animal Model: | Adult male outbred ICR mice[3] | | Dosage: | 1 mg/kg | | Administration: | Pretreated i.p. 24 h before I/R | | Result: | Pretreatment induced delayed protection 24 h later.
Resulted in significant cardioprotection 24 h later, i.e., infarct size was reduced from 38.8 ± 3.7% to 19.8 ± 2.9%.
|
| | storage | +4°C |
| | NS 1619 Preparation Products And Raw materials |
|