3-氟-N'-((5-硝基噻吩-2-基)亞甲基)苯甲酰肼
| 中文名稱 | 3-氟-N'-((5-硝基噻吩-2-基)亞甲基)苯甲酰肼 |
|---|---|
| 中文同義詞 | 3-氟-N'-((5-硝基噻吩-2-基)亞甲基)苯甲酰肼;化合物MITOBLOCK-10;化合物MITOBLOCK-10,10 MM DMSO 溶液 |
| 英文名稱 | 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide |
| 英文同義詞 | 3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)methylidene]benzohydrazide;MitoBloCK-10 (MB-10);Benzoic acid, 3-fluoro-, 2-[(5-nitro-2-thienyl)methylene]hydrazide;3-Fluoro-N'-((5-nitrothiophen-2-yl)methylene)benzohydrazide;MB-10;3-fluoro-N'-[(E)-(5-nitrothiophen-2-yl)m;Mitochondrial,Protein,Tim44,MitoBloCK10,MitoBloCK 10,MitoBloCK-10,inhibit,Inhibitor,Import;MitoBloCK-10, 10 mM in DMSO |
| CAS號 | 394694-98-5 |
| 分子式 | C12H8FN3O3S |
| 分子量 | 293.27 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 394694-98-5.mol |
| 結(jié)構(gòu)式 |  |
3-氟-N'-((5-硝基噻吩-2-基)亞甲基)苯甲酰肼 性質(zhì)
| 密度 | 1.47±0.1 g/cm3(Predicted) |
|---|---|
| 儲存條件 | Store at -20°C |
| 溶解度 | DMSO: 2mg/mL, clear |
| 酸度系數(shù)(pKa) | 11.21±0.46(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 淺黃至黃色 |
| InChI | 1S/C12H8FN3O3S/c13-9-3-1-2-8(6-9)12(17)15-14-7-10-4-5-11(20-10)16(18)19/h1-7H,(H,15,17)/b14-7+ |
| InChIKey | QDYQZMWFIYLMNX-VGOFMYFVSA-N |
| SMILES | Fc1cc(ccc1)C(=O)N\N=C\c2[s]c(cc2)[N+](=O)[O-] |
MitoBloCK-10 (MB-10) 是首個減弱 PAM 復(fù)合體活性的小分子調(diào)節(jié)劑。MitoBloCK-10 (MB-10) 可抑制 C 末端結(jié)構(gòu)域的 Tim44 與前體和 Hsp70 結(jié)合。
MB-10 (100 μM) is a potential attenuator of protein import into mitochondria.
MB-10 inhibits the import of substrates that use the TIM23 import pathway.
MB-10 (0-100 μM) inhibits protein import into mammalian mitochondria.
Cell Viability Assay
| Cell Line: | A plasmid expressing Su9-Ura3-myc was integrated at the LEU2 locus in WT and tim23-2 strains. |
| Concentration: | 100 μM. |
| Incubation Time: | 30 min. |
| Result: | WT strain expressing Su9-Ura3 failed to grow, whereas the tim23-2 mutant expressing Su9-Ura3 grew much faster. The strains grew at a similar rate when the medium was supplemented with uracil. |
Cell Viability Assay
| Cell Line: | HeLa cells. |
| Concentration: | 0-100 μM. |
| Incubation Time: | 24 h. |
| Result: | Inhibited HeLa cells vibility, with an IC 50 of 17.2 μM. |
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲類別 | 11 - 可燃固體 |
| 危險性類別 | 急性毒性 類別4 經(jīng)口 |
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-115467 | 3-氟-N'-((5-硝基噻吩-2-基)亞甲基)苯甲酰肼 MitoBloCK-10 | 394694-98-5 | 500 μg | 500元 |
| 2026/06/05 | HY-115467 | 3-氟-N'-((5-硝基噻吩-2-基)亞甲基)苯甲酰肼 MitoBloCK-10 | 394694-98-5 | 1 mg | 800元 |