LEU-ENKEPHALIN AMIDE manufacturers
- LEU-ENKEPHALIN AMIDE
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- $7.00
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2020-02-19
- CAS: 60117-24-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | LEU-ENKEPHALIN AMIDE Basic information |
| Product Name: | LEU-ENKEPHALIN AMIDE | | Synonyms: | ALPHA-NEOENDORPHIN (1-5) AMIDE;leucine enkephalinamide acetate;DYNORPHIN A (1-5) AMIDE;DYNORPHIN A (1-5) AMIDE ACETATE SALT;H-TYR-GLY-GLY-PHE-LEU-NH2;H-TYR-GLY-GLY-PHE-LEU-NH2 ACETATE SALT;LEU-ENKEPHALIN NH2;LEU-ENKEPHALIN AMIDE | | CAS: | 60117-24-0 | | MF: | C28H38N6O6 | | MW: | 554.64 | | EINECS: | | | Product Categories: | | | Mol File: | 60117-24-0.mol |  |
| | LEU-ENKEPHALIN AMIDE Chemical Properties |
| Melting point | 123-126 °C | | Boiling point | 1012.8±65.0 °C(Predicted) | | density | 1.254±0.06 g/cm3(Predicted) | | storage temp. | −20°C | | solubility | Soluble in DMSO | | form | Solid | | pka | 9.97±0.15(Predicted) | | color | White to off-white | | Sequence | Tyr-Gly-Gly-Phe-Leu-NH2 |
| | LEU-ENKEPHALIN AMIDE Usage And Synthesis |
| Uses | [Leu5]-Enkephalin, amide is a δ opioid receptor agonist. | | in vivo | Levels of [Leu5]-Enkephalin are significantly increased in the nucleus raphe magnus (NRM) of rats 2 weeks after the injection of complete Freund's adjuvant (CFA) (1.02±0.2 pmol/mg protein) as compared with saline-treated rats (0.49±0.04 pmol/mg protein; p<0.01). Tissue levels of [Leu5]-Enkephalin are uniformly increased in the caudal ventrolateral periaqueductal gray (PAG) 4 hr (1.15±0.25 pmol/mg protein), 4 d (1.16±0.18 pmol/mg protein), and 2 weeks (1.18±0.17 pmol/mg protein) after the injection of CFA as compared with saline-treated rats (0.55±0.03 pmol/mg protein; p<0.05, all times). A smaller increase in the levels of [Leu5]-Enkephalin occurred in the rostral aspect of the ventrolateral PAG at all time points. Finally, levels of [Leu5]-Enkephalin are also increased in the contralateral microcellular tegmental nucleus 4 d after the injection of CFA (0.53±0.04 pmol/mg protein) compared with levels in saline-treated rats (0.38±0.02 pmol/mg protein; p<0.05)[1]. | | References | [1] Hurley RW, et al. Contribution of endogenous enkephalins to the enhanced analgesic effects of supraspinal mu opioid receptor agonists after inflammatory injury. J Neurosci. 2001 Apr 1;21(7):2536-45. DOI:10.1523/JNEUROSCI.21-07-02536.2001
[2] Kennedy C, et al. [Met5]enkephalin acts via delta-opioid receptors to inhibit pelvic nerve-evoked contractions of cat distal colon. Br J Pharmacol. 1987 Oct;92(2):291-8. DOI:10.1111/j.1476-5381.1987.tb11323.x |
| | LEU-ENKEPHALIN AMIDE Preparation Products And Raw materials |
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