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| | 3-Morpholinobenzaldehyde Basic information | | Uses |
| Product Name: | 3-Morpholinobenzaldehyde | | Synonyms: | 3-MORPHOLIN-4-YL-BENZALDEHYDE;3-MORPHOLINOBENZALDEHYDE;4-(3-Formylphenyl)morpholine;3-(Morpholin-4-yl)benzaldehyde98%;3-(4-morpholinyl)benzaldehyde;3-(Morpholin-4-yl)benzaldehyde 98%;Benzaldehyde, 3-(4-morpholinyl)-;3-Morpholinobenzaldehyde ISO 9001：2015 REACH | | CAS: | 446866-87-1 | | MF: | C11H13NO2 | | MW: | 191.23 | | EINECS: | | | Product Categories: | Carbonyl Compounds;Heterocycles | | Mol File: | 446866-87-1.mol |  |
| | 3-Morpholinobenzaldehyde Chemical Properties |
| Melting point | 68 °C | | Boiling point | 357.9±37.0 °C(Predicted) | | density | 1.163±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | solid | | pka | 3.80±0.40(Predicted) | | color | Yellow |
| | 3-Morpholinobenzaldehyde Usage And Synthesis |
| Uses | 3-Morphyrinylbenzaldehyde can be used as a pharmaceutical synthesis intermediate. | | Synthesis | To a 500 mL round-bottomed flask was added 3-bromobenzaldehyde (6.44 g, 35.0 mmol, 1.00 eq.), morpholine (9.13 g, 105 mmol, 3.00 eq.), tris(dibenzylideneacetone)dipalladium (1.81 g, 1.75 mmol, 0.05 eq.), dicyclohexyl(2',6'-diisopropoxybiphenyl-2-yl)phosphine ( 3.26 g, 7.00 mmol, 0.20 equiv), cesium carbonate (34.2 g, 105 mmol) under nitrogen, 3.00 equiv), toluene (100 mL). The resulting solution was stirred overnight at 90C and quenched with water (50 mL). The resulting solution was extracted with dichloromethane (3 x 200 mL), the organic layers were combined, washed with brine (3 x 100 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was chromatographed on a silica gel column with ethyl acetate/petroleum ether (3/17) to give 3-morpholino benzaldehyde (2.10 g, 32% yield) as a yellow oil. |
| | 3-Morpholinobenzaldehyde Preparation Products And Raw materials |
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