ML-9鹽酸鹽
| 中文名稱(chēng) | ML-9鹽酸鹽 |
|---|---|
| 中文同義詞 | 1-(5-氯萘磺?；?-1H-六氫-1,4-二氮雜卓, 鹽酸鹽;1-(5-氯萘-1-磺?；?-1H-六氫-1,4-二吖庚因鹽酸鹽;ML-9鹽酸鹽;1-((5-氯萘-1-基)磺?；?-1,4-二氮雜環(huán)庚烷鹽酸鹽;ML-9,蛋白激酶抑制劑;ML-9,蛋白KINASE抑制劑;ML-9鹽酸鹽,10 MM DMSO 溶液;1-(5-氯萘-1-磺酰)-單哌嗪鹽酸鹽 |
| 英文名稱(chēng) | ML-9 HYDROCHLORIDE |
| 英文同義詞 | ML-9;ML-9 HYDROCHLORIDE;1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HCL;1-(5-CHLORONAPHTHALENE-1-SULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HYDROCHLORIDE;1-(5-CHLORONAPHTHALENE-1-SULFONYL)HOMOPIPERAZINE, HCL;1-(5-CHLORONAPHTHALENESULFONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE, HYDROCHLORIDE;1-(5-CHLORONAPHTHALENESULFONYL)HOMOPIPERAZINE HYDROCHLORIDE;1-(5-CHLORONAPHTHALENESULPHONYL)-1H-HEXAHYDRO-1,4-DIAZEPINE HYDROCHLORIDE |
| CAS號(hào) | 105637-50-1 |
| 分子式 | C15H18Cl2N2O2S |
| 分子量 | 361.28 |
| EINECS號(hào) | 200-258-5 |
| 相關(guān)類(lèi)別 | 生化試劑;Protein Kinase Inhibitors and Activators |
| Mol文件 | 105637-50-1.mol |
| 結(jié)構(gòu)式 |  |
ML-9鹽酸鹽 性質(zhì)
| 熔點(diǎn) | 196-200 |
|---|---|
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | 乙醇：10 mg/mL |
| 形態(tài) | 粉末 |
| 顏色 | 白色 |
| 生物來(lái)源 | synthetic (organic) |
| InChI | 1S/C15H17ClN2O2S.ClH/c16-14-6-1-5-13-12(14)4-2-7-15(13)21(19,20)18-10-3-8-17-9-11-18;/h1-2,4-7,17H,3,8-11H2;1H |
| InChIKey | ZNRYCIVTNLZOGI-UHFFFAOYSA-N |
| SMILES | Cl.Clc1cccc2c(cccc12)S(=O)(=O)N3CCCNCC3 |
ML-9 HCl (ML-9 hydrochloride) 是一種有效的選擇性的 Akt kinase、myosin light chain kinase (MLCK) 和 stromal interaction molecule 1 (STIM1)。ML-9 HCl 也是 Ca2+-permeable channels 的有效抑制劑。ML-9 HCl 是一種靶向自噬和細(xì)胞死亡的親溶酶體劑。
| Target | Value |
|
Akt
() | |
|
MLCK
() | |
|
STIM1
() | |
|
Ca2+-permeable channels
() |
ML9 (0-100?μM; 0-24?hours) has no reduction in cardiomyocyte viability, 50-100?μM significantly induces cell death. ML9 (50?μM; 1-4?hours) significantly increases cleaved?caspase-3?levels, decreased STIM1 protein levels by about 42%.
Cell Viability Assay
| Cell Line: | Neonatal rat ventricular?myocytes?(NRVM)?cells |
| Concentration: | 0, 10, 50 and 100?μM |
| Incubation Time: | 0, 1, 4, 8 and 24?hours |
| Result: | Decreased cell viability at 50-100?μM concentration. |
Apoptosis Analysis
| Cell Line: | Neonatal rat ventricular?myocytes?(NRVM)?cells |
| Concentration: | 50?μM |
| Incubation Time: | 1, 4 and 8?hours |
| Result: | Induced cardiomyocyte death through?necrosis?and apoptosis. |
安全信息
| WGK Germany | 3 |
|---|---|
| Hazard Note | Harmful |
| 海關(guān)編碼 | 2935909099 |
| 存儲(chǔ)類(lèi)別 | 11 - 可燃固體 |
| 提供商 | 語(yǔ)言 |
|---|---|
|
英文
|
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | S6847 | ML-9鹽酸鹽 ML-9 HCl | 105637-50-1 | 5mg | 1270.13元 |
| 2026/07/06 | S6847 | ML-9鹽酸鹽 ML-9 HCl | 105637-50-1 | 25mg | 3900.54元 |