BF-168
| 中文名稱 | BF-168 |
|---|---|
| 中文同義詞 | 化合物 T10529;化合物 BF-168 |
| 英文名稱 | BF-168 |
| 英文同義詞 | BF-168;BF 168,BF168;Benzenamine, 4-[2-[6-(2-fluoroethoxy)-2-benzoxazolyl]ethenyl]-N-methyl- |
| CAS號(hào) | 634911-47-0 |
| 分子式 | C18H17FN2O2 |
| 分子量 | 312.34 |
| EINECS號(hào) | |
| 相關(guān)類別 | |
| Mol文件 | 634911-47-0.mol |
| 結(jié)構(gòu)式 | ![]() |
BF-168 性質(zhì)
| 沸點(diǎn) | 511.3±60.0 °C(Predicted) |
|---|---|
| 密度 | 1.258±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Store at -20°C,unstable in solution, ready to use. |
| 溶解度 | 溶于二甲基亞砜 |
| 酸度系數(shù)(pKa) | 4.28±0.42(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 白色至黃色 |
Ki: 6.4 nM (Aβ1-42).
BF-168, a styrylbenzoxazole derivative, is a potent agent that selectively recognizes SPs and NFTs in AD brain. BF-168 is a candidate probe for PET and is found to specifically recognize both neuritic and diffuse plaques, with a K i of 6.4 nM for Aβ1-42.
Intravenous injection of BF-168 in PS1/APP and APP23 transgenic mice result in specific in vivo labeling to both compact and diffuse amyloid deposits in the brain. In addition, 18 F-radiolabeled BF-168 demonstrates abundant initial brain uptake (3.9% injected dose/gm at 2 min after injection) and fast clearance (t 1/2 =24.7 min) after intravenous administration in normal mice. Furthermore, autoradiograms of brain sections from APP23 transgenic mice at 180 min after intravenous injection of [ 18 F]BF-168 shows selective labeling of brain amyloid deposits with little nonspecific binding.
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-112830 | BF-168 | 634911-47-0 | 1 mg | 1150元 |
| 2026/06/05 | HY-112830 | BF-168 BF-168 | 634911-47-0 | 5mg | 3000元 |
