NIGRANOIC ACID
| 中文名稱 | NIGRANOIC ACID |
|---|---|
| 中文同義詞 | 黑五味子酸 |
| 英文名稱 | NIGRANOIC ACID |
| 英文同義詞 | NIGRANOIC ACID;(3S,3aR,4aS,6aR,7R,9aS,9bS)-7-[(1R,4Z)-5-Carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-1H-cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid;1H-Cyclopenta[a]cyclopropa[e]naphthalene-3a(4H)-propanoic acid, 7-[(1R,4Z)-5-carboxy-1-methyl-4-hexen-1-yl]decahydro-6a,9a-dimethyl-3-(1-methylethenyl)-, (3S,3aR,4aS,6aR,7R,9aS,9bS)- |
| CAS號 | 39111-07-4 |
| 分子式 | C30H46O4 |
| 分子量 | 470.69 |
| EINECS號 | |
| 相關(guān)類別 | 中藥對照品 |
| Mol文件 | Mol File |
| 結(jié)構(gòu)式 |  |
NIGRANOIC ACID 性質(zhì)
| 熔點 | 128-130 °C |
|---|---|
| 沸點 | 603.0±28.0 °C(Predicted) |
| 密度 | 1.10±0.1 g/cm3(Predicted) |
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于氯仿、二氯甲烷、乙酸乙酯、DMSO、丙酮等。 |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 4.78±0.10(Predicted) |
| 顏色 | 米白色至淺黃色 |
Nigranoic acid 是五味子中分離得到的一種三萜類化合物。Nigranoic acid 能抑制 HIV-1 逆轉(zhuǎn)錄酶。在腦缺血再灌注動物模型中，Nigranoic acid 通過 PARP/AIF 信號通路保護大腦。
HIV-1 reverse transcriptase
Nigranoic acid has a strong protective effect on rat cerebral ischemia-reperfusion injury, and acts by downregulating nerve cell apoptosis by preventing the overactivation of PARP and AIF nuclear translocation.
Nigranoic acid (1 mg/kg; i.g.; 6 hours and 2 hours before brain ischemia) significantly decreases apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points.
| Animal Model: | Sprague–Dawley rats (200-300 g), ischemia–reperfusion model |
| Dosage: | 1 mg/kg |
| Administration: | Intragastric; 6 hours and 2 hours before brain ischemia |
| Result: | Decreased apoptosis and the expression levels of AIF protein, PARP protein, and AIF mRNA at different time-points. |
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-122935 | Nigranoic acid | 39111-07-4 | 1 mg | 1950元 |
| 2026/06/05 | HY-122935 | NIGRANOIC ACID Nigranoic acid | 39111-07-4 | 5mg | 4900元 |