| Company Name: |
Sichuan Wei Keqi Biological Technology Co., Ltd.
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| Tel: |
028-81700200 18116577057 |
| Email: |
3003855609@qq.com |
| Products Intro: |
Product Name:PROTACIRAK4degrader-1
CAS:2360533-90-8
Purity:98% Package:5mg；10mg；20mg；50mg；100mg；200mg；500mg；1g
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| Company Name: |
Chengdu Novel Biomedical Co., Ltd.
|
| Tel: |
028-85255396 18302801538 |
| Email: |
cdnovell@163.com |
| Products Intro: |
Product Name:PROTAC IRAK4
CAS:2360533-90-8
Purity:98%+ Package:1g;500mg Remarks:DZ-2024-179
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| | PROTAC IRAK4 degrader-1 Basic information |
| Product Name: | PROTAC IRAK4 degrader-1 | | Synonyms: | PROTAC IRAK4 degrader-1;2-{2-[(cyclopropylmethyl)amino]pyridin-4-yl}-N-{1-[4-({3-[4-({[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}methyl)-1H-imidazol-1-yl]propyl}carbamoyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-4-yl}-1,3-oxazole-4-carboxamide;PROTAC IRAK4;IRAK4 PROTAC compound I-210 | | CAS: | 2360533-90-8 | | MF: | C44H39F3N12O7 | | MW: | 904.85 | | EINECS: | | | Product Categories: | | | Mol File: | 2360533-90-8.mol |  |
| | PROTAC IRAK4 degrader-1 Chemical Properties |
| density | 1.61±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | pka | 10.74±0.40(Predicted) | | form | Solid | | color | White to yellow |
| | PROTAC IRAK4 degrader-1 Usage And Synthesis |
| Uses | PROTAC IRAK4 degrader-1 is a Cereblon-based PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes <20%, >20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively[1]. | | Biological Activity | PROTAC IRAK4 degrader-1 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes 20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively[1]. | | IC 50 | IRAK4; Cereblon | | References | [1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1. |
| | PROTAC IRAK4 degrader-1 Preparation Products And Raw materials |
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