2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- manufacturers
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| | 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Basic information |
| Product Name: | 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- | | Synonyms: | 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-;3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione;Lenalidomide-6-F;2-(2,6-dioxopiperidin-3-yl)-6-fluoro-1-oxo-2,3-dihydro-1H-isoindol;3-(6-Fluoro-1-oxo-2-isoindolinyl)piperidine-2,6-dione | | CAS: | 2468780-87-0 | | MF: | C13H11FN2O3 | | MW: | 262.24 | | EINECS: | | | Product Categories: | | | Mol File: | 2468780-87-0.mol |  |
| | 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Chemical Properties |
| Boiling point | 534.5±50.0 °C(Predicted) | | density | 1.461±0.06 g/cm3(Predicted) | | storage temp. | Storage temp. 2-8°C | | pka | 10.63±0.40(Predicted) | | form | Solid | | color | Gray to gray purple | | InChI | InChI=1S/C13H11FN2O3/c14-8-2-1-7-6-16(13(19)9(7)5-8)10-3-4-11(17)15-12(10)18/h1-2,5,10H,3-4,6H2,(H,15,17,18) | | InChIKey | HNAQSGYWVZTYEF-UHFFFAOYSA-N | | SMILES | N1C(=O)CCC(N2CC3=C(C2=O)C=C(F)C=C3)C1=O |
| | 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Usage And Synthesis |
| Uses | Lenalidomide-6-F is the Lenalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Lenalidomide-6-F can be connected to the ligand for protein by a linker to form PROTAC[1]. | | IC 50 | Cereblon | | References | [1] Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25. DOI:10.1016/j.csbj.2019.01.006
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277 |
| | 2,6-Piperidinedione, 3-(6-fluoro-1,3-dihydro-1-oxo-2H-isoindol-2-yl)- Preparation Products And Raw materials |
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