L-803,087 TRIFLUOROACETATE
| 中文名稱 | L-803,087 TRIFLUOROACETATE |
|---|---|
| 中文同義詞 | 化合物 T11800;(4-(5,7-二氟-2-苯基-1H-吲哚-3-基)丁?；?-L-精氨酸甲酯;化合物 L-803087;化合物L(fēng)-803087,10 MM DMSO 溶液;L-803,087三氟乙酸鹽 |
| 英文名稱 | L-803,087 TRIFLUOROACETATE |
| 英文同義詞 | N2-[4-(5,7-DIFLUORO-2-PHENYL-1H-INDOL-3-YL)-1-OXOBUTYL]-L-ARGININE METHYL ESTER TRIFLUOROACETATE;L-803,087 TRIFLUOROACETATE;L-Arginine, N2-[4-(5,7-difluoro-2-phenyl-1H-indol-3-yl)-1-oxobutyl]-, methyl ester;L803087,L 803087;Methyl (4-(5,7-difluoro-2-phenyl-1H-indol-3-yl)butanoyl)-L-argininate;L-803087, 10 mM in DMSO |
| CAS號(hào) | 217480-26-7 |
| 分子式 | C25H29F2N5O3 |
| 分子量 | 485.53 |
| EINECS號(hào) | |
| 相關(guān)類別 | Somatostatin receptor |
| Mol文件 | 217480-26-7.mol |
| 結(jié)構(gòu)式 |  |
L-803,087 TRIFLUOROACETATE 性質(zhì)
| 密度 | 1.33±0.1 g/cm3(Predicted) |
|---|---|
| 儲(chǔ)存條件 | Store at -20°C |
| 溶解度 | 在 DMSO 中溶解度為 100 mM，在乙醇中溶解度為 100 mM |
| 形態(tài) | 粉末 |
| 酸度系數(shù)(pKa) | 14.54±0.46(Predicted) |
| 顏色 | 白色至淺黃色 |
Ki: 0.7 nM (sst4 receptor), 199 nM (sst1 receptor), 4720 nM (sst2 receptor), 1280 nM (sst3 receptor) and 3880 nM (sst5 receptor)
L-803087 has
K
i
values for cloned human sst1, sst2, sst3 and sst5 receptors of 199, 4720, 1280 and 3880 nM, respectively.
L-803087 has a diamine moiety that maps to lysine on the phmacophore, but relation of this molecule to the aromatic and the Trp substituents of the phmacophore are not obvious. L-803087 does not inhibit secretion of growth hormone, insulin, or glucagon.
L-803087 (5 nmol) is doubled seizure activity in wild-type mice on average. Interestingly, this effect is blocked by 3 nmol Octreotide. In hippocampal slices from wild-type mice, Octreotide (2 μM) does not modify AMPA-mediated synaptic responses while facilitation occurred with L-803087 (2 μM).
安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-108497 | L-803,087 TRIFLUOROACETATE L-803087 | 217480-26-7 | 1 mg | 1400元 |
| 2026/06/05 | HY-108497 | L-803,087 TRIFLUOROACETATE L-803087 | 217480-26-7 | 5 mg | 3500元 |