| Company Name: |
Beijing Jin Ming Biotechnology Co., Ltd.
|
| Tel: |
010-60605840 15801484223; |
| Email: |
psaitong@jm-bio.com |
| Products Intro: |
Product Name:Guanoxabenz hydrochloride
CAS:23256-40-8
Purity:98% Package:5mg;10mg;25mg;50mg;100mg
|
| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
|
| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:Guanoxabenz hydrochloride
CAS:23256-40-8
Purity:95% Package:2mg;5mg;25mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Guanoxabenz hydrochloride
CAS:23256-40-8
Package:2mg/RMB 2890;5mg/RMB 3320;25mg/RMB 13900
|
3-[(2,6-dichlorophenyl)methylene]-N-hydroxycarbazamidine monohydrochloride manufacturers
|
| | 3-[(2,6-dichlorophenyl)methylene]-N-hydroxycarbazamidine monohydrochloride Basic information |
| | 3-[(2,6-dichlorophenyl)methylene]-N-hydroxycarbazamidine monohydrochloride Chemical Properties |
| Melting point | 173-175° | | storage temp. | Store at -20°C | | solubility | DMSO : 83.33 mg/mL (293.89 mM) | | form | Solid | | color | Off-white to gray |
| | 3-[(2,6-dichlorophenyl)methylene]-N-hydroxycarbazamidine monohydrochloride Usage And Synthesis |
| Uses | Guanoxabenz (Hydroxyguanabenz) hydrochloride is an α2 adrenergic receptor agonist, with a Ki of 4000 nM and the fully activated form 40 nM for an α2A adrenoceptor[1][2][3]. | | in vivo | Guanoxabenz and guanabenz are both known as centrally active antihypertensive drugs. High affinity Guanoxabenz binding is induced in rat brain membranes after addition of NADH or NADPH cofactors. The rat cerebral cortex contains an enzymatic activity that may activate Guanoxabenz leading to formation of a metabolite showing high affinity for alpha 2-adrenoceptors[3].
Guanoxabenz (0.1-3 mg/kg, i.p.) causes a dose-related reduction in locomotor activity; a dose of 1 mg/kg is selected since this induces a pronounced and sustained behavioural hypoactivity[4].
| Animal Model: | Rats[4]. | | Dosage: | 0.5 mg/kg (RX 781094 or saline vehicle was injected intravenously (tail vein) at the time of peak effect of the agonist (20min for clonidine and 30 min for Guanoxabenz). | | Administration: | IP. | | Result: | RX 781094 (0.1-1.0 mg/kg, i.v.) produces a rapid (< 5 set) and complete antagonism of the EEG and behavioural effects induced by clonidine and Guanoxabenz. |
| | References | [1] Uhlén S, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at alpha2-adrenoceptors. I. Description of an enzymatic activity in spleen membranes. Biochem Pharmac DOI:10.1016/s0006-2952(98)00135-x
[2] Dambrova M, et al. Characterization of the enzymatic activity for biphasic competition by guanoxabenz (1-(2,6-dichlorobenzylidene-amino)-3-hydroxyguanidine) at alpha2-adrenoceptors. II. Description of a xanthine-dependent enzymatic activity in spleen cyto DOI:10.1016/s0006-2952(98)00136-1
[3] Dambrova M, et al. Characterization of Guanoxabenz reducing activity in rat brain. Pharmacol Toxicol. 1998 Oct;83(4):158-63. DOI:10.1111/j.1600-0773.1998.tb01462.x
[4] P W Dettmar, et al. Neuropharmacological studies in rodents on the action of RX 781094, a new selective alpha 2-adrenoceptor antagonist. Neuropharmacology. 1983 Jun;22(6):729-37. DOI:10.1016/0028-3908(83)90097-7 |
| | 3-[(2,6-dichlorophenyl)methylene]-N-hydroxycarbazamidine monohydrochloride Preparation Products And Raw materials |
|