醋酸普羅瑞林
| 中文名稱 | 醋酸普羅瑞林 |
|---|---|
| 中文同義詞 | 醋酸普羅瑞林?, >99%;醋酸普羅瑞林;Protirelin acetate-醋酸普羅瑞林;Protirelin acetate-醋酸普羅瑞林 |
| 英文名稱 | Protirelin acetate |
| 英文同義詞 | Protirelin acetate;Protirelin Acetate,TRF Acetate,TRH Acetate,TSH-RF Acetate, >99%;TRF Acetate;TRH Acetate;TSH-RF Acetate |
| CAS號 | 120876-23-5 |
| 分子式 | C38H56N12O14 |
| 分子量 | 904.92324 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 120876-23-5.mol |
| 結(jié)構(gòu)式 |  |
醋酸普羅瑞林 性質(zhì)
| 儲存條件 | Store at -20°C |
|---|---|
| 形態(tài) | 固體 |
| 顏色 | 白色至米白色 |
| 水溶解性 | Water : 50 mg/mL (110.51 mM) |
| 序列 | {pGlu}-His-Pro-NH2 |
醋酸普羅瑞林（Protirelin acetate）是Protirelin的醋酸鹽形式，可用于改善精神分裂癥患者的面部表情、情感融洽和精神運(yùn)動等癥狀。Protirelin 是內(nèi)源性肽促甲狀腺激素釋放激素 （TRH） 的醫(yī)藥合成類似物，由下丘腦釋放的三肽嗜性激素，可刺激垂體前葉釋放促甲狀腺激素 （TSH） 和催乳素。
Protirelin Acetate 是一種高度保守的神經(jīng)肽，發(fā)揮促甲狀腺激素 (TSH) 水平的激素控制作用，及神經(jīng)調(diào)節(jié)功能。Thyroid hormone receptor
Protirelin (TRH) is an evolutionarily ancient neuropeptide, having its origin before the divergence of protostomes and deuterostomes, and may ancestrally have been involved in the control of postembryonic growth and reproduction. The effect of the thyrotropin-releasing hormone (Protirelin, TRH), one of the hypothalamic releasing hormones, on body temperature is investigated in the rat. Protirelin, in doses of 1, 5, 10 and 20 mg/kg, is injected intraperitoneally to male Wistar rats weighing 200-250 g. Protirelin causes a temporary rise in body temperature dose-dependently. The thyroidectomized rats injected 20 mg/kg of Protirelin which induces a significant hyperthermia in the sham-operated animals, fail to show a rise in body temperature. The present results suggest that a release of thyroid hormone might participate in the hyperthermic action of Protirelin.
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-P0002A | 醋酸普羅瑞林 Protirelin acetate | 120876-23-5 | 5 mg | 420元 |
| 2026/06/05 | HY-P0002A | 120876-23-5 Protirelin acetate | 120876-23-5 | 10mg | 700元 |