(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide

(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide Suppliers list
Company Name: Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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CAS:1215115-03-9
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CAS:1215115-03-9
Purity:98% Package:$320.9/5mg;$550.9/10mg;$1200.9/25mg;Bulk package Remarks:98%
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Products Intro: Product Name:KH-3
CAS:1215115-03-9
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Products Intro: Product Name:(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide
CAS:1215115-03-9
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Products Intro: Product Name:KH-3
CAS:1215115-03-9
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(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide manufacturers

  • KH-3
  • KH-3 pictures
  • $1270.00
  • 2026-05-11
  • CAS:1215115-03-9
  • Purity:
  • Supply Ability: 10g
(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide Basic information
Product Name:(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide
Synonyms:(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide;2-Propenamide, 3-[5-[[[4-(1,1-dimethylethyl)phenyl]sulfonyl]amino]benzo[b]thien-2-yl]-N-hydroxy-, (2E)-;HuR inhibitor KH-3
CAS:1215115-03-9
MF:C21H22N2O4S2
MW:430.54
EINECS:
Product Categories:
Mol File:1215115-03-9.mol
(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide Structure
(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide Chemical Properties
density 1.374±0.06 g/cm3(Predicted)
pka8.39±0.30(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide Usage And Synthesis
UsesKH-3 is a potent RNA-binding protein Hu antigen R (HuR) inhibitor with an IC50 value of 0.35 μM. KH-3 has anti-proliferative activity. KH-3 suppresses breast cancer cell invasion as well as delays the initiation of lung colonies by disrupting HuR-FOXQ1 mRNA interaction[1].
in vivo

KH-3 (100 mg/kg; i.p.; three times a week for three weeks; female athymic NCr-nu/nu mice and BALB/c mice) inhibits breast cancer growth and metastasis in vivo[1].

Animal Model:Female athymic NCr-nu/nu mice of MDA-MB-231 orthotopic xenograft and BALB/c mice of MDA-MB-231 orthotopic xenograft[1]
Dosage:100 mg/kg
Administration:Intraperitoneal injection; three times a week for three weeks
Result:Inhibited tumor growth, resulting in 60% tumor regression after three-week treatment and delayed the initiation of pulmonary metastases.
Reduced the protein expression levels of HuR targets in tumor tissues as well as the induction of E-cadherin expression.
References[1] Wu X, et, al. Targeting the interaction between RNA-binding protein HuR and FOXQ1 suppresses breast cancer invasion and metastasis. Commun Biol. 2020 Apr 24;3(1):193. DOI:10.1038/s42003-020-0933-1
(2E)-3-[5-(4-tert-butylbenzenesulfonamido)-1-benz othiophen-2-yl]-N-hydroxyprop-2-enamide Preparation Products And Raw materials
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