NCH-51
| 中文名稱 | NCH-51 |
|---|---|
| 中文同義詞 | 化合物PTACH;S-[7-氧代-7-[(4-苯基-1,3-噻唑-2-基)氨基]庚基]-2-甲基丙硫酸酯;S-(7-氧代-7-((4-苯基噻唑-2-基)氨基)庚基) 2-甲基硫代丙酸酯;NCH 51,新型HDAC抑制劑;NCH 51,HDAC抑制劑;化合物PTACH,10 MM DMSO 溶液;NCH-51 (NCH51);NCH 51,新型HDAC抑制劑【CAS:848354-66-5】【規(guī)格:5mg】【純度:98%】 |
| 英文名稱 | PTACH |
| 英文同義詞 | Cpd 51, S-[6-(4-Phenyl-2-thiazolylcarbamoyl)hexyl] thioisobutyrate;2-MethylpropanethioicacidS-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl]ester;S-(7-Oxo-7-((4-phenylthiazol-2-yl)amino)-heptyl) 2-methylpropanethioate;PTACH (NCH-51);HDAC Inhibitor XXII, NCH51;Propanethioic acid,2-methyl-, S-[7-oxo-7-[(4-phenyl-2-thiazolyl)amino]heptyl] ester;NCH51, >98%;PTACH?, >98% |
| CAS號(hào) | 848354-66-5 |
| 分子式 | C20H26N2O2S2 |
| 分子量 | 390.56 |
| EINECS號(hào) | |
| 相關(guān)類別 | 標(biāo)準(zhǔn)品 |
| Mol文件 | 848354-66-5.mol |
| 結(jié)構(gòu)式 |  |
NCH-51 性質(zhì)
| 熔點(diǎn) | 127-128 °C(Solv: hexane (110-54-3); ethyl acetate (141-78-6)) |
|---|---|
| 密度 | 1.181±0.06 g/cm3(Predicted) |
| 儲(chǔ)存條件 | 2-8°C |
| 溶解度 | 在DMSO中的溶解度為26mg/mL |
| 形態(tài) | 白色粉末 |
| 酸度系數(shù)(pKa) | 9.52±0.50(Predicted) |
| 顏色 | 白色至米白色 |
| InChI | 1S/C20H26N2O2S2/c1-15(2)19(24)25-13-9-4-3-8-12-18(23)22-20-21-17(14-26-20)16-10-6-5-7-11-16/h5-7,10-11,14-15H,3-4,8-9,12-13H2,1-2H3,(H,21,22,23) |
| InChIKey | MDYDGUOQFUQOGE-UHFFFAOYSA-N |
| SMILES | CC(C)C(=O)SCCCCCCC(=O)Nc1nc(cs1)-c2ccccc2 |
|
HDAC1 48 nM (IC 50 ) |
HDAC4 32 nM (IC 50 ) |
HDAC6 41 nM (IC 50 ) |
HIV-1
|
PTACH (compound 51) treatment elevates the levels of acetylated histone H4 and p21
WAF1/CIP1
in a dose-dependent manner.
In cancer cell growth inhibition assay, PTACH (compound 51) shows strong activity. PTACH inhibits various cancer cells with EC50 values of 2.3 μM, 9.1 μM, 3.0 μM, 2.6 μM, 1.1 μM, 4.5 μM, 2.4 μM, 5.0 μM, and 4.5 μM for MDA-MB-231, SNB-78, HCT116, NCI-H226, LOX-IMVI, SK-OV-3, RXF-631L, St-4, and DU-145 cells, respectively.
PTACH (NCH-51) augments the HIV-1 production in latently infected OM10.1 cells and such reactivation is associated with a loss of HDAC1 occupancy and subsequent hyperacetylation of histones in nuc-1 at the HIV-1 promoter.
Western Blot Analysis
| Cell Line: | HCT 116 cells |
| Concentration: | 1 μM, 5 μM, 25 μM |
| Incubation Time: | 8 hours |
| Result: | Gave rise to elevated and dose-dependent levels of acetylated histone H4 and p21 WAF1/CIP1 . |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-12954 | NCH-51 PTACH | 848354-66-5 | 1 mg | 560元 |
| 2026/06/05 | HY-12954 | NCH-51 PTACH | 848354-66-5 | 5 mg | 1780元 |