- Exatecan
-
- $30.00
-
2026-07-15
- CAS:171335-80-1
- Purity: 99.96%
- Supply Ability: 10g
- Exatecan
-
- $30.00
-
2026-07-15
- CAS:171335-80-1
- Purity: 99.96%
- Supply Ability: 10g
- Exatecan
-
-
2025-12-16
- CAS:171335-80-1
- Min. Order: 10mg
- Purity: 99%+ HPLC
- Supply Ability: 1000
|
| | Exatecan Basic information |
| Product Name: | Exatecan | | Synonyms: | 10H,13H-BENZO[DE]PYRANO[3',4':6,7]INDOLIZINO[1,2-B]QUINOLINE-10,13-DIONE, 1-AMINO-9-ETHYL-5-FLUORO-1,2,3,9,12,15-HEXAHYDRO-9-HYDROXY-4-METHYL-, (1S,9S)-, MONOMETHANESULFONATE (SALT);(1S,9S)-1-Amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-10H,13H-benzo(de)pyrano(3',4':6,7)indolizino(1,2-b)quinoline-10,13-dione;Exatecan;CS-147;Exatecan Impurity;10H,13H-Benzo[de]pyrano[3',4':6,7]indolizino[1,2-b]quinoline-10,13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1S,9S)-;Irinotecan Impurity 36;1 Exatecan | | CAS: | 171335-80-1 | | MF: | C24H22FN3O4 | | MW: | 435.45 | | EINECS: | | | Product Categories: | | | Mol File: | 171335-80-1.mol |  |
| | Exatecan Chemical Properties |
| Boiling point | 818.4±65.0 °C(Predicted) | | density | 1.53±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C,protect from light | | solubility | Soluble in DMSO | | form | Solid | | pka | 11.19±0.40(Predicted) | | color | Off-white to gray | | InChIKey | ZVYVPGLRVWUPMP-FYSMJZIKSA-N | | SMILES | N1C2C3=C(CC[C@H](N)C3=C3CN4C(C=13)=CC1[C@](CC)(O)C(=O)OCC=1C4=O)C(C)=C(F)C=2 |
| RIDADR | UN2811 | | WGK Germany | WGK 3 | | HazardClass | 6.1 | | Storage Class | 6.1A - Combustible acute toxic Cat. 1 and 2
very toxic hazardous materials | | Hazard Classifications | Acute Tox. 2 Oral
Muta. 1B
Repr. 1B |
| | Exatecan Usage And Synthesis |
| Description | Exatecan is a hexacyclic chemical compound analogous to camptothecin and used as a payload in ADC research. Exatecan mesylate is used as an inhibitor of DNA topoisomerase I, which plays a key role in DNA replication, transcription, and recombination. | | Definition | ChEBI: Exatecan is a pyranoindolizinoquinoline. | | Biological Activity | Exatecan (DX-8951) is a DNA topoisomerase I (topoisomerase I) inhibitor with IC50 of 2.2 μM (0.975 μg/mL) for cancer research. | | in vitro | Exatecan is a potent topoisomerase I inhibitor, with an IC 50 of 0.975 μg/mL. Exatecan Mesylate (DX-8951f) significantly inhibits the proliferation of several cancer cell lines, with mean GI 50 s of 2.02 ng/mL, 2.92 ng/mL, 1.53 ng/mL, and 0.877 ng/mL for breast cancer cells, colon cancer cells, stomach cancer cells and lung cancer cells, respectively. Exatecan Mesylate (DX-8951f) displays cytotoxic activities against PC-6, PC-6/SN2-5 cells, with mean GI 50 s of 0.186 and 0.395 ng/mL, respctively. Exatecan Mesylate (34 nM) stabilizes DNA-TopoI complexes in PC-6 and PC-6/SN2-5 cells. | | in vivo | Exatecan Mesylate (DX-8951f, 3.325-50 mg/kg, i.v.) exhibits antitumor activities in the mice model bearing tumor cells, without toxic death. Exatecan Mesylate (15, 25 mg/kg, i.v.) hightly inhibits MIA-PaCa, BxPC-3 primary tumor growth in the MIA-PaCa-2 early-stage model and early-stage model of BxPC-3. Exatecan Mesylate (15, 25 mg/kg, i.v.) also significantly suppresses BxPC-3 lymphatic metastasis and completely eliminates lung metastasis in the BxPC-3 late-stage cancer model. |
| | Exatecan Preparation Products And Raw materials |
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