N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine manufacturers
- Glycinocholic acid
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2026-06-08
- CAS:474-74-8
- Min. Order: 1KG
- Purity: 0.99
- Supply Ability: 1000KG
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| | N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine Basic information |
| Product Name: | N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine | | Synonyms: | N-[(3α,5β)-3-Ηydroxy-24-oxocholan-24-yl]glycine;N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine;Ursodeoxycholic Impurity 13;Glycine, N-[(3α,5β)-3-hydroxy-24-oxocholan-24-yl]-;Glycolithocholic Acid MaxSpec? Standard;Glycine, N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-;primary,glycine,Glycolithocholic acid,non-alcoholic,NASH,colitis,sclerosing,inhibit,ulcerative,bile,steatohepatitis,PSC,acid,diagnose,Endogenous Metabolite,Inhibitor,cholangitis;Urosodeoxycholic Acid Impurity 13 | | CAS: | 474-74-8 | | MF: | C26H43NO4 | | MW: | 433.63 | | EINECS: | 207-494-9 | | Product Categories: | Intermediates & Fine Chemicals;Metabolites & Impurities;Inhibitors;Pharmaceuticals;Steroids | | Mol File: | 474-74-8.mol | ![N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine Structure](CAS/GIF/474-74-8.gif) |
| | N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine Chemical Properties |
| Melting point | 212-214 °C | | Boiling point | 546.95°C (rough estimate) | | density | 1.0738 (rough estimate) | | refractive index | 1.6000 (estimate) | | storage temp. | Refrigerator | | solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Heated) | | form | Solid | | pka | 3.58±0.10(Predicted) | | color | White to Off-White | | InChIKey | XBSQTYHEGZTYJE-LNYAHCOINA-N | | SMILES | C[C@]12CC[C@]3([H])[C@]4(CC[C@@H](O)C[C@@]4([H])CC[C@@]3([H])[C@]1([H])CC[C@]2([H])[C@H](C)CCC(=O)NCC(=O)O)C |&1:1,4,6,9,12,16,18,22,24,r| |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine Usage And Synthesis |
| Description | Glycolithocholic acid is a glycine-conjugated form of the secondary bile acid lithocholic acid . It is increased in the liver of mice fed a diet supplemented with ursodeoxycholic acid . Glycolithocholic acid levels are decreased in the plasma following subcutaneous administration of PEG-obestatin(Cys10, Cys13), a modified peptide hormone, in lean or diet-induced obese mice. Serum glycolithocholic acid levels increase with age in children. | | Uses | A metabolite in human hepatic bile. A lithocholic acid analog that inhibit sialyltransferase. | | Definition | ChEBI: The glycine conjugate of lithocholic acid. | | in vivo | The concentrations of Glycolithocholic acid in ulcerative colitis (UC) patients were significantly lower than those in healthy controls (HCs)[2]. | | IC 50 | Microbial Metabolite | | References | [1] P. LEFEBVRE. Role of bile acids and bile acid receptors in metabolic regulation.[J]. Physiological reviews, 2009, 89 1 1: 147-191. DOI: 10.1152/physrev.00010.2008
[2] YOUCAI ZHANG Curtis D K. Effects of feeding bile acids and a bile acid sequestrant on hepatic bile acid composition in mice.[J]. Journal of Lipid Research, 2010, 51 11: 3230-3242. DOI: 10.1194/jlr.m007641
[3] ELAINE COWAN. Treatment of lean and diet-induced obesity (DIO) mice with a novel stable obestatin analogue alters plasma metabolite levels as detected by untargeted LC-MS metabolomics.[J]. Metabolomics, 2016, 12: 124. DOI: 10.1007/s11306-016-1063-0
[4] RICHARD D SEMBA. Environmental Enteric Dysfunction Is Associated With Altered Bile Acid Metabolism.[J]. Journal of Pediatric Gastroenterology and Nutrition, 2017, 64 4: 536-540. DOI: 10.1097/mpg.0000000000001313 |
| | N-[(3a,5b)-3-hydroxy-24-oxocholan-24-yl]-(9CI) Glycine Preparation Products And Raw materials |
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