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| | 1-Fluoro-2-nitrobenzene Basic information |
| | 1-Fluoro-2-nitrobenzene Chemical Properties |
| Melting point | -9--6 °C (lit.) | | Boiling point | 116 °C/22 mmHg (lit.) | | density | 1.338 g/mL at 25 °C (lit.) | | vapor pressure | 3.09Pa at 25℃ | | refractive index | n20/D 1.532(lit.) | | Fp | 202 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | Chloroform, Ethyl Acetate, Methanol | | form | Liquid | | Specific Gravity | 1.338 | | color | deep greenish-yellow | | Water Solubility | immiscible | | BRN | 607262 | | InChI | 1S/C6H4FNO2/c7-5-3-1-2-4-6(5)8(9)10/h1-4H | | InChIKey | PWKNBLFSJAVFAB-UHFFFAOYSA-N | | SMILES | [O-][N+](=O)c1ccccc1F | | LogP | 1.69 | | CAS DataBase Reference | 1493-27-2(CAS DataBase Reference) | | NIST Chemistry Reference | Benzene, 1-fluoro-2-nitro-(1493-27-2) | | EPA Substance Registry System | Benzene, 1-fluoro-2-nitro- (1493-27-2) |
| Hazard Codes | Xi,T,Xn | | Risk Statements | 36/37/38-20/21/22 | | Safety Statements | 26-36-36/37 | | RIDADR | 2810 | | WGK Germany | 3 | | Hazard Note | Toxic/Irritant | | TSCA | TSCA listed | | HazardClass | 6.1 | | PackingGroup | III | | HS Code | 29049085 | | Storage Class | 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects | | Hazard Classifications | Acute Tox. 3 Dermal
Acute Tox. 4 Inhalation
Acute Tox. 4 Oral
Aquatic Chronic 2
STOT RE 1 |
| | 1-Fluoro-2-nitrobenzene Usage And Synthesis |
| Chemical Properties | clear yellow to brownish liqui | | Uses | o-Nitrofluorobenzene is an intermediate in the synthetic preparations of various pharmaceutical goods. | | Uses | 1-Fluoro-2-nitrobenzene is an intermediate in the synthetic preparations of various pharmaceutical goods. | | Synthesis Reference(s) | Tetrahedron, 52, p. 23, 1996 DOI: 10.1016/0040-4020(95)00867-8
Tetrahedron Letters, 26, p. 2233, 1985 DOI: 10.1016/S0040-4039(00)98970-6 | | Synthesis | Take choline chloride (0.28g,2mmol) and urea (0.12g,2mmol) to form a low eutectic, add o-chloronitrobenzene (2mmol), potassium fluoride (10mmol) and DMSO (2.5ml), heating to 160 , the reaction for 8 hours. Cool down to room temperature, add water 10ml,stir well, add ethyl acetate (10ml×3) to extract the aqueous layer, combine the organic layer, saturated brine wash (10ml×3) the organic layer. MgSO4 drying, spinning evaporation, to get the crude product, separated by column chromatography, to get the product 1 -fluoro-2-nitrobenzene.
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| | 1-Fluoro-2-nitrobenzene Preparation Products And Raw materials |
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