2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇
| 中文名稱 | 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇 |
|---|---|
| 中文同義詞 | 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇;芬戈莫德-D4;芬格莫德及中間體;芬戈莫德堿;芬戈莫德 FINGOLIMOD;芬戈莫德,10 MM DMSO 溶液;化合物:Fingolimod;Fingolimod試劑 |
| 英文名稱 | Gilenia |
| 英文同義詞 | 2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;Fingolimod(FTY720);Gilenia;2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propandiol;FingoliMod Base;fenogliMod;1,3-Propanediol,2-aMino-2-[2-(4-octylphenyl)ethyl]-;Fingolise |
| CAS號(hào) | 162359-55-9 |
| 分子式 | C19H33NO2 |
| 分子量 | 307.47 |
| EINECS號(hào) | 1308068-626-2 |
| 相關(guān)類別 | 原料藥;醫(yī)藥中間體;中間體;醫(yī)藥原料;藥物雜質(zhì)及中間體;系列1;pharmaceutical intermediate;API |
| Mol文件 | 162359-55-9.mol |
| 結(jié)構(gòu)式 | ![]() |
2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇 性質(zhì)
| 熔點(diǎn) | 103-105° |
|---|---|
| 沸點(diǎn) | 479.5±45.0 °C(Predicted) |
| 密度 | 1.016 |
| 儲(chǔ)存條件 | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| 溶解度 | 氯仿(稍微加熱)、DMSO(稍微加熱)、甲醇(稍微加熱) |
| 酸度系數(shù)(pKa) | 12.20±0.20(Predicted) |
| 形態(tài) | 固體 |
| 顏色 | 米白色 |
| InChI | InChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3 |
| InChIKey | KKGQTZUTZRNORY-UHFFFAOYSA-N |
| SMILES | C(O)C(N)(CCC1=CC=C(CCCCCCCC)C=C1)CO |
| Target | Value |
|
S1P receptor
() |
The monocyte-derived immature dendritic cells (iDCs) are pretreated with various concentrations of S1P for various periods of time prior to their incubation with NK cells. Four hours incubation of autologous or allogeneic iDCs with 0.2-20 μM of S1P significantly protectes these cells from NK cell lysis. The IC 50 values of S1P are calculated at 160 nM for autologous iDCs, and 34 nM for allogeneic iDCs. Next, the inhibitory effect of S1P is revered by various concentrations of Fingolimod or SEW2871, with an IC 50 effect of 173 or 15 nM, respectively. Fingolimod has been reported to reduce LPA synthesis via inhibition of the lysophospholipase autotaxin. Fingolimod treatment correlates with a significant elevation of axonal cAMP, a crucial factor for axonal outgrowth. Additionally, Fingolimod significantly reduces LPA levels in the injured nerve. PF-8380 treatment correlates with improved myelin thickness.
Fingolimod treatment results in significantly increased nerve conduction at 14 days post-crush in wildtype C57BL/6 mice. However, Foxn1 -/- mice, which are devoid of T- but not B-lymphocytes, show an improvement of nerve regeneration under fingolimod treatment. Although the mean increase in nerve conduction velocity in both fingolimod-treated and control Foxn1 -/- mice implies a potentially positive role of T-lymphocyte deficiency on nerve regeneration, only fingolimod-treated Foxn1 -/- mice show a significant improvement compared to C57BL/6 controls and performed better in the functional analysis. Treatment of the animals with Fingolimod for 28 d results in a clear reduction in the binding of 18 F-GE180 when compare with vehicle-treated animals and evaluated by ex vivo autoradiography. Quantification of the binding of the radiotracer revealed a significant reduction in the binding potential of 18 F-GE180 (P<0.0001) after treatment with Fingolimod.
安全信息
| WGK Germany | WGK 3 |
|---|---|
| 存儲(chǔ)類別 | 11 - 可燃固體 |
| 危險(xiǎn)性類別 | 急性毒性 類別4 經(jīng)口 危害水生環(huán)境-急性危害 類別1 危害水生環(huán)境-長(zhǎng)期危害 類別1 生殖毒性 類別2 經(jīng)皮刺激 類別2 特異性靶器官毒性-反復(fù)接觸類別2 |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2026/07/06 | S5950 | 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇 Fingolimod | 162359-55-9 | 10mg | 876.42元 |
| 2026/07/06 | S5950 | 2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇 Fingolimod | 162359-55-9 | 100mg | 4669.1元 |
![2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇 結(jié)構(gòu)式](CAS/20180808/GIF/162359-55-9.gif)