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2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇

2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇

中文名稱2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇
中文同義詞2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇;芬戈莫德-D4;芬格莫德及中間體;芬戈莫德堿;芬戈莫德 FINGOLIMOD;芬戈莫德,10 MM DMSO 溶液;化合物:Fingolimod;Fingolimod試劑
英文名稱Gilenia
英文同義詞2-Amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol;Fingolimod(FTY720);Gilenia;2-Amino-2-[2-(4-octylphenyl)ethyl]-1,3-propandiol;FingoliMod Base;fenogliMod;1,3-Propanediol,2-aMino-2-[2-(4-octylphenyl)ethyl]-;Fingolise
CAS號(hào)162359-55-9
分子式C19H33NO2
分子量307.47
EINECS號(hào)1308068-626-2
相關(guān)類別原料藥;醫(yī)藥中間體;中間體;醫(yī)藥原料;藥物雜質(zhì)及中間體;系列1;pharmaceutical intermediate;API
Mol文件162359-55-9.mol
結(jié)構(gòu)式2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇 結(jié)構(gòu)式

2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇 性質(zhì)

熔點(diǎn)103-105°
沸點(diǎn)479.5±45.0 °C(Predicted)
密度1.016
儲(chǔ)存條件Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
溶解度氯仿(稍微加熱)、DMSO(稍微加熱)、甲醇(稍微加熱)
酸度系數(shù)(pKa)12.20±0.20(Predicted)
形態(tài)固體
顏色米白色
InChIInChI=1S/C19H33NO2/c1-2-3-4-5-6-7-8-17-9-11-18(12-10-17)13-14-19(20,15-21)16-22/h9-12,21-22H,2-8,13-16,20H2,1H3
InChIKeyKKGQTZUTZRNORY-UHFFFAOYSA-N
SMILESC(O)C(N)(CCC1=CC=C(CCCCCCCC)C=C1)CO

2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇 用途與合成方法

Fingolimod (FTY-720A, FTY-720)是S1PR調(diào)節(jié)劑,用于治療緩解型多發(fā)性硬化癥。
TargetValue
S1P receptor
()

The monocyte-derived immature dendritic cells (iDCs) are pretreated with various concentrations of S1P for various periods of time prior to their incubation with NK cells. Four hours incubation of autologous or allogeneic iDCs with 0.2-20 μM of S1P significantly protectes these cells from NK cell lysis. The IC 50 values of S1P are calculated at 160 nM for autologous iDCs, and 34 nM for allogeneic iDCs. Next, the inhibitory effect of S1P is revered by various concentrations of Fingolimod or SEW2871, with an IC 50 effect of 173 or 15 nM, respectively. Fingolimod has been reported to reduce LPA synthesis via inhibition of the lysophospholipase autotaxin. Fingolimod treatment correlates with a significant elevation of axonal cAMP, a crucial factor for axonal outgrowth. Additionally, Fingolimod significantly reduces LPA levels in the injured nerve. PF-8380 treatment correlates with improved myelin thickness.

Fingolimod treatment results in significantly increased nerve conduction at 14 days post-crush in wildtype C57BL/6 mice. However, Foxn1 -/- mice, which are devoid of T- but not B-lymphocytes, show an improvement of nerve regeneration under fingolimod treatment. Although the mean increase in nerve conduction velocity in both fingolimod-treated and control Foxn1 -/- mice implies a potentially positive role of T-lymphocyte deficiency on nerve regeneration, only fingolimod-treated Foxn1 -/- mice show a significant improvement compared to C57BL/6 controls and performed better in the functional analysis. Treatment of the animals with Fingolimod for 28 d results in a clear reduction in the binding of 18 F-GE180 when compare with vehicle-treated animals and evaluated by ex vivo autoradiography. Quantification of the binding of the radiotracer revealed a significant reduction in the binding potential of 18 F-GE180 (P<0.0001) after treatment with Fingolimod.

安全信息

WGK GermanyWGK 3
存儲(chǔ)類別11 - 可燃固體
危險(xiǎn)性類別急性毒性 類別4 經(jīng)口
危害水生環(huán)境-急性危害 類別1
危害水生環(huán)境-長(zhǎng)期危害 類別1
生殖毒性 類別2
經(jīng)皮刺激 類別2
特異性靶器官毒性-反復(fù)接觸類別2

MSDS信息

更新日期產(chǎn)品編號(hào)產(chǎn)品名稱CAS號(hào)包裝價(jià)格
2026/07/06S59502-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇
Fingolimod
162359-55-910mg876.42元
2026/07/06S59502-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇
Fingolimod
162359-55-9100mg4669.1元
"2-氨基-2-[2-(4-辛基苯基)乙基]-1,3-丙二醇"相關(guān)產(chǎn)品信息
鹽酸芬戈莫德 芬戈莫德雜質(zhì) 芬戈莫德雜質(zhì)D 芬戈莫德棕櫚酸酯酰胺 蘇戈莫德雜質(zhì)4 4-(2-碘代乙基)辛基苯 芬戈莫德-D4 2-二甲基亞氨基芬戈莫德 FTY720-d4Hydrochloride 二乙基2-乙酰胺基-2-(4-辛基苯乙基)丙二酸酯 乙酸-[2-(4-辛基苯基)]乙醇 Fingolimod 芬戈莫德雜質(zhì) 2-NitrodeaMinoFingoliMod 2-(乙酰氨基)-2-[2-(4-辛基苯基)-2-氧代乙基]-丙二酸1,3-二乙酯 N-(1-羥基-2-(羥甲基)-4-(4-辛基苯基)丁-2-基)乙酰胺 異亞硝基丙二酸二乙酯
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