10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine
| 中文名稱 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine |
|---|---|
| 中文同義詞 | 化合物PSB-12062;10-對甲苯磺?；?10H-吩噁嗪;化合物PSB-12062,10 MM DMSO 溶液;10-[(4-甲基苯基)磺酰基]-10H吩惡嗪 |
| 英文名稱 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine |
| 英文同義詞 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine;PSB-12062;10-Tosyl-10H-phenoxazine;N-(p-Methylphenylsulfonyl)phenoxazine;10H-Phenoxazine, 10-[(4-methylphenyl)sulfonyl]-;PSB-12062 >=98% (HPLC);P2X Receptor,Inhibitor,PSB12062,PSB 12062,PSB-12062,P2XRs,inhibit;PSB-12062, 10 mM in DMSO |
| CAS號 | 55476-47-6 |
| 分子式 | C19H15NO3S |
| 分子量 | 337.39 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 55476-47-6.mol |
| 結(jié)構(gòu)式 | ![10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine 結(jié)構(gòu)式](CAS/GIF/55476-47-6.gif) |
10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine 性質(zhì)
| 儲存條件 | 2-8°C |
|---|---|
| 溶解度 | DMSO：可溶，2mg/mL，澄清（加熱） |
| 形態(tài) | 粉末 |
| 顏色 | 白色至米色 |
| InChI | 1S/C19H15NO3S/c1-14-10-12-15(13-11-14)24(21,22)20-16-6-2-4-8-18(16)23-19-9-5-3-7-17(19)20/h2-13H,1H3 |
| InChIKey | DHZNMEIBMACSFH-UHFFFAOYSA-N |
| SMILES | [S](=O)(=O)(N2c3c(cccc3)Oc4c2cccc4)c1ccc(cc1)C |
PSB-12062是有效，選擇性的 P2X4 拮抗劑，對人類 P2X4 的 IC50 值為1.38 μM。
IC50: 1.38 μM (human P2X4), 92.8 nM (rat P2X4), 1.76 μM (mouse P2X4)
PSB-12062 shows similar potency in human, rat, and mouse species. PSB-12062 shows to be allosteric in nature with a 35-fold selectivity toward P2X4 versus P2X1, P2X2, P2X3, and P2X7. However, PSB-12062 is unable to completely block ATP-induced P2X4-mediated calcium influx even when used at high concentrations (>30 μM).
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-101910 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine PSB-12062 | 55476-47-6 | 5mg | 340元 |
| 2026/06/05 | HY-101910 | 10-[(4-Methylphenyl)sulfonyl]-10H-phenoxazine PSB-12062 | 55476-47-6 | 10mM * 1mLin DMSO | 374元 |