血卟啉二鹽酸鹽
| 中文名稱 | 血卟啉二鹽酸鹽 |
|---|---|
| 中文同義詞 | 血卟啉IX二氯化氫;鹵代卟啉鹽酸鹽;血卟啉二鹽酸鹽;二鹽酸血紫素;血卟啉鹽酸鹽;血卟啉鹽酸鹽(一水);血紫素鹽酸鹽;鹽酸血紫素 |
| 英文名稱 | HEMATOPORPHYRIN DIHYDROCHLORIDE |
| 英文同義詞 | 21h,23h-porphine-2,18-dipropanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;21h,23h-porphine-2,18-propanoicacid,7,12-bis(1-hydroxyethyl)-3,8,13,17-tetr;7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-2,18-porphinedipropionicacid;acido1,3,5,8-tetrametil-2,4-bis(idrossietil)porpfina-6,7-dipropionicodiclor;ematoporfirina;HEMATOPORPHYRIN IX DIHYDROCHLORIDE;HEMATOPORPHYRIN DIHYDROCHLORIDE;HAEMATOPORPHYRIN DIHYDROCHLORIDE |
| CAS號(hào) | 17696-69-4 |
| 分子式 | C34H39ClN4O6 |
| 分子量 | 635.16 |
| EINECS號(hào) | 241-699-4 |
| 相關(guān)類別 | 醫(yī)藥原料;Natural Porphyrins and Derivitives;Porphyrins;Biochemistry;Miscellaneous Biochemicals;porphine (porphyrin) ligand |
| Mol文件 | 17696-69-4.mol |
| 結(jié)構(gòu)式 |  |
血卟啉二鹽酸鹽 性質(zhì)
| 儲(chǔ)存條件 | Inert atmosphere,Room Temperature |
|---|---|
| 溶解度 | 可溶于DMSO（少許）、甲醇（少許） |
| 形態(tài) | 固體 |
| 顏色 | 深紅色 |
| 水溶解性 | Insoluble in water. Soluble in pyridine (5%). |
| Merck | 14,4636 |
| BRN | 78957 |
| 穩(wěn)定性 | 吸濕性 |
| EPA化學(xué)物質(zhì)信息 | 21H,23H-Porphine-2,18-dipropanoic acid, 7,12-bis(1-hydroxyethyl)-3,8,13,17-tetramethyl-, dihydrochloride (17696-69-4) |
有研究表明血卟啉二鹽酸鹽可用于制備具有高結(jié)晶速率的樹脂組合物，其包含聚呋喃二甲酸亞烷基酯(polyalkylenefurandicarboxylate)樹脂和卟啉化合物。該聚呋喃二甲酸亞烷基酯樹脂優(yōu)選為聚呋喃二甲酸亞丁基酯樹脂。該卟啉化合物優(yōu)選為血卟啉二鹽酸鹽(hematoporphyrindihydrochloride)。Hematoporphyrin dihydrochloride (Hematoporphyrin IX dihydrochloride) 是一種光敏劑，是血紅素結(jié)合蛋白親和色譜底物。當(dāng)暴露于紅光下時(shí)，Hematoporphyrin dihydrochloride 可以誘導(dǎo) U87 膠質(zhì)瘤細(xì)胞凋亡，并降低體內(nèi)腫瘤的生長。
Hematoporphyrin (20-120 nM; 60 min) dose-dependently inhibits cell viability in U87 and U251 glioma cells, with IC
50
s of 85 and 166 nM, respectively.
Hematoporphyrin (85 nM; 60 min) induces cell apoptosis via induction of ROS in U87 cells.
Hematoporphyrin (85 nM; 60 min) induces morphological changes of U87 cells under the red light, including shrinking, fragmentation.
Cell Viability Assay
| Cell Line: | U87 and U251 cells |
| Concentration: | 20, 40, 60, 80, 100, 120 nM |
| Incubation Time: | 60 min |
| Result: |
Inhibited cell viability in a dose-dependent manner.
Was more effective under the red light than white light. |
Apoptosis Analysis
| Cell Line: | U87 cells |
| Concentration: | 85 nM |
| Incubation Time: | 60 min |
| Result: |
Induced apoptotic nuclei in U87 cells with low cell density.
Induced the ROS and decreased the mitochondrial membrane potential. |
Hematoporphyrin (5-10 mg/kg; i.p. for 2 months) with the irradiation of red light rapidly decreases the tumor size of rats, due to necrosis caused both by direct action of the photoactivated porphyrin on the tumor cells and by secondary effects on blood vessels.
| Animal Model: | Wistar albino rats of both sexes (20 d; 60-80 g) bearing a subcutaneous solid Yoshida hepatoma AH-130 |
| Dosage: | 5, 10 mg/kg |
| Administration: | I.p. daily during the initial 10 days and biweekly for the next 2 months |
| Result: |
No tumor could be palpated a few days after exposure of the rats to light.
The skin healed completely and regrowth of the hair occurred. Massive coagulation necrosis of the tumor 24 h after phototreatment (×40). |
安全信息
| 危險(xiǎn)類別碼 | 33 |
|---|---|
| RTECS號(hào) | TS5505000 |
| TSCA | TSCA listed |
| 毒性 | mouse,LD50,intraperitoneal,169mg/kg (169mg/kg),BEHAVIORAL: TREMORBEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY),Bollettino Chimico Farmaceutico. Vol. 117, Pg. 145, 1978. |
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱 | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2025/12/22 | HY-B0754A | 血卟啉二鹽酸鹽 Hematoporphyrin dihydrochloride | 17696-69-4 | 100mg | 343元 |
| 2025/05/22 | XW1769669401 | 血卟啉二鹽酸鹽 | 17696-69-4 | 250MG | 307元 |