噻哌溴銨
| 中文名稱 | 噻哌溴銨 |
|---|---|
| 中文同義詞 | 3-(二噻吩-2-基亞甲基)-5-甲氧基-1,1-二甲基-1-哌啶溴化物;噻哌溴銨;化合物 T12825;化合物 TIMEPIDIUM BROMIDE |
| 英文名稱 | Timepidium bromide |
| 英文同義詞 | TIMEPIDIUM BROMIDE;1,1-Dimethyl-5-methoxy-3-(dithien-2-ylmethylene)piperidinium bromide;Mepidium;Piperidinium, 3-(di-2-thienylmethylene)-5-methoxy-1,1-dimethyl-, bromide (9CI);SA 504;SA 50Y;Sesden;3-[Di(2-thienyl)methylene]-5-methoxy-1,1-dimethylpiperidinium |
| CAS號 | 35035-05-3 |
| 分子式 | C17H22BrNOS2 |
| 分子量 | 400.4 |
| EINECS號 | |
| 相關(guān)類別 | |
| Mol文件 | 35035-05-3.mol |
| 結(jié)構(gòu)式 |  |
噻哌溴銨 性質(zhì)
| 熔點 | 198-200° |
|---|---|
| 儲存條件 | Store at -20°C |
| 溶解度 | 溶于二甲基亞砜 |
Timepidium bromide (Sesden; SA504) 是一種抗膽堿劑。
Cholinergic
Effects of Timepidium bromide (TB), acetylcholine (ACh) and neostigmine (Neost) on gastric and duodenal blood flow distribution are studied by the use of 131 I-labeled macroaggregated human serum albumin (MAA) in rabbits. In normal rabbits, gastric blood flow is found to be uneven in various regions of the stomach: anterior corpus (50% of total gastric blood flow) greater than posterior corpus (40%) greater than pyloric antrum (7%). Intravenous administration of Timepidium bromide (200 μg/kg) to normal rabbits produces a slight increase in total gastric blood flow, but the increase in the mucosal layer of the pyloric antrum is considerable.