N-(2-((4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide
概述 用途與合成方法 MSDS N-(2-((4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide價格(試劑級) 上下游產(chǎn)品信息
| 中文名稱 | N-(2-((4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide |
|---|---|
| 中文同義詞 | 化合物 T12429;N-(2-((4AR,6S,8AR)-2-氨基-6-甲基-4,4A,5,6-四氫吡喃并[3,4-D][1,3]噻嗪-8A(8H)-基)噻唑-4-基)-5-(二氟甲氧基)吡啶-2-甲酰胺;化合物 PF-06751979;PF-06751979 抑制劑;PF-06751979 抑制劑 |
| 英文名稱 | N-(2-((4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide |
| 英文同義詞 | N-(2-((4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide;EOS-62090;2-Pyridinecarboxamide, N-[2-[(4aR,6S,8aR)-2-amino-4,4a,5,6-tetrahydro-6-methylpyrano[3,4-d][1,3]thiazin-8a(8H)-yl]-4-thiazolyl]-5-(difluoromethoxy)-;PF 06751979,PF06751979 |
| CAS號 | 1818339-66-0 |
| 分子式 | C18H19F2N5O3S2 |
| 分子量 | 455.5 |
| EINECS號 | |
| 相關類別 | |
| Mol文件 | 1818339-66-0.mol |
| 結構式 | ![N-(2-((4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide 結構式](CAS/20180703/GIF/1818339-66-0.gif) |
N-(2-((4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide 性質
| 密度 | 1.66±0.1 g/cm3(Predicted) |
|---|---|
| 儲存條件 | Store at -20°C |
| 溶解度 | DMSO：150 mg/mL (329.31 mM)；乙醇：50 mg/mL (109.77 mM) |
| 形態(tài) | 固體 |
| 酸度系數(shù)(pKa) | 10+-.0.70(Predicted) |
| 顏色 | 白色至米白色 |
N-(2-((4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide 用途與合成方法
PF-06751979 是一種有效的，腦滲透性的 β-淀粉樣前體蛋白裂解酶1 (BACE1) 抑制劑，IC50 為 7.3 nM。
安全信息
| 更新日期 | 產(chǎn)品編號 | 產(chǎn)品名稱 | CAS號 | 包裝 | 價格 |
|---|---|---|---|---|---|
| 2026/06/05 | HY-112157 | N-(2-((4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide PF-06751979 | 1818339-66-0 | 1 mg | 1520元 |
| 2026/06/05 | HY-112157 | N-(2-((4aR,6S,8aR)-2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide PF-06751979 | 1818339-66-0 | 5 mg | 3800元 |