| Company Name: |
BOC Sciences
|
| Tel: |
16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CAY10669
CAS:1243583-88-1
Purity:98% Package:1G;10G;100G Remarks:P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a co-activator of p53-target genes and moreover it regulates p53 activity by acetylating K320, which promote
|
| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:CAY10669
CAS:1243583-88-1
Purity:>98% Package:1mg;10mg;50mg;100mg;
|
| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:CAY10669
CAS:1243583-88-1
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
CAY10669 manufacturers
- CAY10669
-
- $1290.00
-
2026-05-11
- CAS:1243583-88-1
- Purity:
- Supply Ability: 10g
|
| | CAY10669 Basic information |
| Product Name: | CAY10669 | | Synonyms: | CAY10669;JZTUSBQKQHUSQE-FLIBITNWSA-N;CAY-10669,CAY10669;Benzoic acid, 2-hydroxy-6-[(1Z)-2-[4-(pentyloxy)phenyl]ethenyl]-;2-hydroxy-6-[(1Z)-2-[4-(pentyloxy)phenyl]ethenyl]-benzoicacid | | CAS: | 1243583-88-1 | | MF: | C20H22O4 | | MW: | 326.39 | | EINECS: | | | Product Categories: | | | Mol File: | 1243583-88-1.mol |  |
| | CAY10669 Chemical Properties |
| Boiling point | 516.8±50.0 °C(Predicted) | | density | 1.192±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: 30 mg/ml | | form | A crystalline solid | | pka | 2.93±0.30(Predicted) |
| | CAY10669 Usage And Synthesis |
| Description | CAY10669 is an inhibitor of the histone acetyltransferase PCAF. | | Uses | CAY10669 (compound 6d) is an anacardic acid (HY-N2020) derivative that inhibits histone acetyltransferase PCAF with an IC50 of 662 μM[1]. CAY10669 enhances the SAHA-induced acetylation in HEPG2 cells, exhibits cytotoxicity in zebrafish embryo, promotes transgene expression in CHO-K1 cells[1][2][3]. | | IC 50 | PCAF: 662 μM (IC50) | | References | [1] Ghizzoni M, et al., Improved inhibition of the histone acetyltransferase PCAF by an anacardic acid derivative. Bioorg Med Chem. 2010 Aug 15;18(16):5826-34. DOI:10.1016/j.bmc.2010.06.089
[2] Farr GH 3rd, et al., A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy. Skelet Muscle. 2020 Oct 15;10(1):29. DOI:10.1186/s13395-020-00251-4
[3] Christensen MD, et al., An inhibitor screen identifies histone-modifying enzymes as mediators of polymer-mediated transgene expression from plasmid DNA. J Control Release. 2018 Sep 28;286:210-223. DOI:10.1016/j.jconrel.2018.06.030 |
| | CAY10669 Preparation Products And Raw materials |
|