ChemicalBook > Product Catalog >Biochemical Engineering >Biochemical Reagents >Agonist Inhibitors >N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate

N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate

N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate Suppliers list
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Products Intro: Product Name:Avitinib maleate
CAS:1557268-88-8
Purity:98% HPLC LCMS Package:10G;20G
Company Name: TargetMol Chemicals Inc.
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Products Intro: Product Name:Avitinib maleate
CAS:1557268-88-8
Purity:99.77% Package:5mg;67USD|10mg;117USD|25mg;219USD Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Hubei Ipure Biology Co., Ltd
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Products Intro: Product Name:Avitinib Maleate
CAS:1557268-88-8
Purity:0.99 Package:5KG;1KG
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Products Intro: Product Name:Avitinib maleate
CAS:1557268-88-8
Purity:0.99, AD68 Package:1g;1USD
Company Name: HONG KONG IPURE BIOLOGY CO.,LIMITED
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Email: ada@ipurechemical.com
Products Intro: Product Name:Avitinib Maleate
CAS:1557268-88-8
Purity:.99 Package:5KG;1KG
N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate Basic information
Product Name:N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate
Synonyms:Avitinib (maleate);N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate;AC 0010.;AC-0010;AC0010MA; AC-0010MA; AC 0010MA; AC0010; AC-0010; AC 0010.;2-Propenamide, N-[3-[[2-[[3-fluoro-4-(4-methyl-1-piperazinyl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]phenyl]-, (2Z)-2-butenedioate (1:1);Avitinib (AC0010) maleate;HER1,Abivertinib,EGFR,Inhibitor,Avitinib,AC0010,Epidermal growth factor receptor,Avitinib maleate,inhibit,ErbB-1,AC-0010,AC 0010
CAS:1557268-88-8
MF:C30H30FN7O6
MW:603.6009032
EINECS:
Product Categories:
Mol File:1557268-88-8.mol
N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate Structure
N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate Chemical Properties
storage temp. Store at -20°C
solubility DMSO:100.0(Max Conc. mg/mL);165.67(Max Conc. mM)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate Usage And Synthesis
UsesAvitinib (Abivertinib) maleate is a third-generation, irreversible and orally active selective EGFR inhibitor, with IC50 values of 0.18 nM, 0.18 nM, 7.68 nM and against EGFR L858R, EGFR T790M and wild-type EGFR. Avitinib maleate is also a BTK inhibitor that induces apoptosis and inhibits phosphorylation of BTK in mantle cell lymphoma. Avitinib maleate shows anticancer effects[1][2].
in vivo

Avitinib (AC0010; 12.5-500 mg/kg; orally administration; once daily; for 14 days) maleate inhibits EGFR-mutant tumor growth but not wild-type EGFR tumor growth in xenograft models over extended duration[1].

Animal Model:Nu/Nu nude mice (Six- to 8-week-old) injected with NCI-H1975 and A431 cells[1]
Dosage:12.5, 50, and 500 mg/kg
Administration:Orally administration; once daily; for 14 days
Result:Inhibited EGFR-mutant tumor growth but not wild-type EGFR tumor growth.
IC 50EGFR L858R: 0.18 nM (IC50); EGFRT790M: 0.18 nM (IC50); EGFR (WT): 7.68 nM (IC50)
References[1] Xu X, et al. AC0010, an Irreversible EGFR Inhibitor Selectively Targeting Mutated EGFR and Overcoming T790M-Induced Resistance in Animal Models and Lung Cancer Patients. Mol Cancer Ther. 2016 Nov;15(11):2586-2597. DOI:10.1158/1535-7163.MCT-16-0281
[2] Yan X, et al. Promising efficacy of novel BTK inhibitor AC0010 in mantle cell lymphoma. J Cancer Res Clin Oncol. 2018;144(4):697-706. DOI:10.1007/s00432-017-2570-8
N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate Preparation Products And Raw materials
Tag:N-(3-((2-((3-Fluoro-4-(4-methylpiperazin-1-yl)phenyl)amino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)phenyl)acrylamide maleate(1557268-88-8) Related Product Information