C 87 manufacturers
- C 87
-
- $39.00
-
2026-04-22
- CAS:332420-90-3
- Purity: ≥98%
- Supply Ability: 10g
- C 87
-
- $39.00
-
2026-04-22
- CAS:332420-90-3
- Purity: ≥98%
- Supply Ability: 10g
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| Product Name: | C 87 | | Synonyms: | C 87;3-Phenyl-1-(4-phenyl-2-thiazolyl)-1H-pyrazole-4,5-dione 4-[2-(4-chloro-3-nitrophenyl)hydrazone];C87; C-87;1H-Pyrazole-4,5-dione, 3-phenyl-1-(4-phenyl-2-thiazolyl)-, 4-[2-(4-chloro-3-nitrophenyl)hydrazone];TNFalpha-IN-C87;TNF Receptor,inhibit,Tumor Necrosis Factor Receptor,C 87,C87,Inhibitor,C-87,TNFR;C 87, 10 mM in DMSO;TNF-TNFR Interaction Modulator, C87 | | CAS: | 332420-90-3 | | MF: | C24H15ClN6O3S | | MW: | 502.93 | | EINECS: | | | Product Categories: | | | Mol File: | 332420-90-3.mol |  |
| Boiling point | 667.5±65.0 °C(Predicted) | | density | 1.51±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 9.33 mg/mL (18.55 mM);Water : < 0.1 mg/mL (insoluble) | | form | Solid | | pka | 5.95±0.40(Predicted) | | color | Yellow to orange |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| Uses | 3-Phenyl-1-(4-phenyl-2-thiazolyl)-4-[(4-chloro-3-nitrophenyl)hydrazone]-1H-pyrazole-4,5-dione is a TNF alpha inhibitor. It also weakens inflammation and increases survival in a mouse hepatitis model. | | Biological Activity | Cell permeable: yes', 'Primary Target
TNFα', 'Reversible: yes', 'Target Ki: 110 nM for hTNF&alpha | | in vivo | C 87 (C87) attenuates TNFα-induced inflammation, thereby markedly reducing injuries to the liver and improving animal survival. C 87 injection delays the incidence of death and increases the survival rate by two folds compared with the vehicle control. The level of alanine transaminase and aspartate transaminase is consistently reduced in mice with C 87 treatment[1]. | | storage | Store at +4°C |
| | C 87 Preparation Products And Raw materials |
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