1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-pyrazole-3-carbonitrile

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Products Intro: Product Name:COX-2-IN-2
CAS:134729-13-8
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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CAS:134729-13-8
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Products Intro: Product Name:1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-pyrazole-3-carbonitrile
CAS:134729-13-8
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Products Intro: Product Name:COX-2-IN-2
CAS:134729-13-8
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CAS:134729-13-8
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1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-pyrazole-3-carbonitrile Basic information
Product Name:1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-pyrazole-3-carbonitrile
Synonyms:1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-pyrazole-3-carbonitrile;COX-2-IN-2;1H-Pyrazole-3-carbonitrile, 1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-;COX2IN2,COX 2 IN 2;COX-2-IN-2, 10 mM in DMSO
CAS:134729-13-8
MF:C17H12FN3O2S
MW:341.3594832
EINECS:
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Mol File:134729-13-8.mol
1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-pyrazole-3-carbonitrile Structure
1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-pyrazole-3-carbonitrile Chemical Properties
Boiling point 563.6±50.0 °C(Predicted)
density 1.33±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka-5.89±0.10(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-pyrazole-3-carbonitrile Usage And Synthesis
UsesCOX-2-IN-2 is a selective and inducible COX2 inhibitor with an IC50 of 0.24 μM. COX-2-IN-1 is an anti-inflammatory compound with anti-inflammatory and analgesic activities.
in vivo

COX-2-IN-2 has oral ED50 values of 0.030 and 0.47mg/kg on adjuvant-induced arthritis and collagen-induced arthritis, respectively, and an ED30 value of 7.4mg/kg in the yeast-induced hyperalgesia (Randall-Selitto) assay. COX-2-IN-2 shows good analgesic activity and no ulcerogenicity[1].

IC 50COX-2: 240 nM (IC50)
References[1] Tsuji K, et al. Studies on anti-inflammatory agents. IV. Synthesis and pharmacological properties of 1,5-diarylpyrazoles and related derivatives. Chem Pharm Bull (1997), 45(6), 987-995.
1-(4-fluorophenyl)-5-[4-(methylsulfonyl)phenyl]-pyrazole-3-carbonitrile Preparation Products And Raw materials
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