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| | 5-(4-Bromophenyl)furfural Basic information |
| Product Name: | 5-(4-Bromophenyl)furfural | | Synonyms: | 5-(4-BROMOPHENYL)-2-FURALDEHYDE;5-(4-BROMOPHENYL)-2-FURANCARBALDEHYDE;5-(4-BROMOPHENYL)-2-FURANCARBOXALDEHYDE;5-(4-BROMO-PHENYL)-FURAN-2-CARBALDEHYDE;5-(4-BROMOPHENYL)FURFURAL;5-(4-Bromophenyl)-2-furancarboxaldehyde 98%;5-(4-BROMOPHENYL)FURFURAL 97%;5-(4-Bromophenyl)furan-2-carboxaldehyde 98% | | CAS: | 20005-42-9 | | MF: | C11H7BrO2 | | MW: | 251.08 | | EINECS: | | | Product Categories: | | | Mol File: | 20005-42-9.mol |  |
| | 5-(4-Bromophenyl)furfural Chemical Properties |
| Melting point | 152-155 °C(lit.) | | Boiling point | 371.9±32.0 °C(Predicted) | | density | 1.518±0.06 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | powder to crystal | | color | Orange to Amber to Dark red | | InChI | 1S/C11H7BrO2/c12-9-3-1-8(2-4-9)11-6-5-10(7-13)14-11/h1-7H | | InChIKey | QRTAOOSYSVHQGT-UHFFFAOYSA-N | | SMILES | Brc1ccc(cc1)-c2ccc(C=O)o2 | | CAS DataBase Reference | 20005-42-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36-37/39 | | WGK Germany | 3 | | HazardClass | IRRITANT | | HS Code | 29321900 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Eye Irrit. 2
Skin Irrit. 2
STOT SE 3 |
| | 5-(4-Bromophenyl)furfural Usage And Synthesis |
| Chemical Properties | brown powder | | Uses | 5-(4-Bromophenyl)furfural is an aromatic aldehyde. Oxone oxidation of 5-(4-bromophenyl)furfural has been reported to afford γ-keto carboxylic acid. | | General Description | 5-(4-Bromophenyl)furfural is an aromatic aldehyde. Oxone oxidation of 5-(4-bromophenyl)furfural has been reported to afford γ-keto carboxylic acid. | | Synthesis | GENERAL STEPS: 1.00 mmol of p-bromoiodobenzene, 1.30 mmol of 5-formylfuran-2-boronic acid, and 0.05 mmol of bis(triphenylphosphine)palladium(II) dichloride were added to the reaction flask under argon protection. Subsequently, 0.30 mL of dimethoxyethane, 0.50 mL of ethanol, and 0.30 mL of 2M sodium carbonate aqueous solution were added. The reaction mixture was heated to 65 °C and the reaction was stirred for 1 hour or monitored by thin layer chromatography (TLC) until the feedstock completely disappeared. After completion of the reaction, the mixture was concentrated and extracted three times with ethyl acetate. The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated. The crude product was purified by silica gel column chromatography with petroleum ether/ethyl acetate (9:1, v/v) as eluent. | | References | [1] European Journal of Medicinal Chemistry, 2017, vol. 126, p. 929 - 936
[2] European Journal of Medicinal Chemistry, 2018, vol. 150, p. 698 - 718 |
| | 5-(4-Bromophenyl)furfural Preparation Products And Raw materials |
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